{"id":"W4416790610","doi":"10.1128/msystems.00862-25","title":"<i>Bifidobacterium animalis</i> subsp. <i>lactis</i> Probio-M8 enhances chondroitin efficacy for knee osteoarthritis in postmenopausal women via the gut-joint axis","year":2025,"lang":"en","type":"article","venue":"mSystems","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Osteoarthritis; Pathogenesis; Inflammation; Chondroitin sulfate; Chondroitin; Postmenopausal women; Probiotic","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003735687,0.0003174141,0.0009683269,0.0001857671,0.0002188149,0.0002952478,0.0002709531,0.0004415323,0.001334923],"category_scores_gemma":[0.0002899924,0.0001848131,0.0004316103,0.0001348906,0.0002158854,0.0002152234,0.0002613201,0.0005160319,0.0001708651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007255,"about_ca_system_score_gemma":0.000391761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001309615,"about_ca_topic_score_gemma":0.002352251,"domain_scores_codex":[0.9998547,0.00004336814,0.00001607884,0.00002370665,0.00002126727,0.0000409631],"domain_scores_gemma":[0.9998404,0.00001887246,0.00004989349,0.00001137874,0.00001986656,0.00005951467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.3579245,0.02075534,0.005539365,0.001262427,0.000710075,0.0001244312,0.000156614,0.0002092948,0.5425737,0.00009732193,0.0004753244,0.07017157],"study_design_scores_gemma":[0.03816869,0.8039177,0.06062017,0.000206327,0.001467977,0.0002611167,0.00031843,0.000970126,0.08994666,0.00009598427,0.003995237,0.000031514],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976525,0.001767136,0.00009646164,0.0001048253,0.00002732021,0.00008606404,0.00006811955,0.00001309423,0.0001844033],"genre_scores_gemma":[0.9970642,0.001173707,0.0006971501,0.0001465427,0.00003902303,0.000113696,0.0001558792,0.000003603786,0.0006061305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334923,"threshold_uncertainty_score":0.004465818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006758133263337384,"score_gpt":0.2417673297350899,"score_spread":0.2350091964717525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}