{"id":"W4416791413","doi":"10.21203/rs.3.rs-8118227/v1","title":"Sex-influenced DNA methylation differs by placental cell type","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; BC Children's Hospital","keywords":"Placenta; DNA methylation; Umbilical cord; Cytotrophoblast; CpG site; Somatic cell; Cell type; Methylation; Dosage compensation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000220558,0.0001854737,0.0002947463,0.0007277594,0.0001408396,0.0004971561,0.0003069288,0.0002288409,0.005972361],"category_scores_gemma":[0.0008141479,0.0002639782,0.0002324028,0.0003237249,0.0002349769,0.0002506691,0.0002787973,0.0003006774,0.0008406802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001989023,"about_ca_system_score_gemma":0.0001288506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007843535,"about_ca_topic_score_gemma":0.000505445,"domain_scores_codex":[0.9998306,0.00003749907,0.000007870705,0.00005622314,0.00003370962,0.0000340145],"domain_scores_gemma":[0.9996629,0.0001486429,0.00004944406,0.00005495327,0.00003625403,0.00004786564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007193388,0.00001400509,0.01125536,0.0000452409,0.00003120189,0.0002207756,0.0001579075,0.00004092472,0.9798269,0.0004321319,0.00008218722,0.00717415],"study_design_scores_gemma":[0.00003256062,0.0002816043,0.3706106,0.00001932459,0.0001306613,0.003014904,0.0003516619,0.0005982014,0.6190972,0.001158213,0.004683459,0.00002162629],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878422,0.002198307,0.003298121,0.00009458021,0.00003883815,0.00001339413,0.001173085,0.00008864726,0.0052528],"genre_scores_gemma":[0.9948872,0.0007405951,0.0006189421,0.00002040934,0.00001112283,0.00001111806,0.0006091627,0.00006422609,0.003037249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005972361,"threshold_uncertainty_score":0.01997954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02598915274840725,"score_gpt":0.3650827447581642,"score_spread":0.3390935920097569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}