{"id":"W4416794320","doi":"10.1038/s41467-025-65776-y","title":"TOR and heat shock response pathways regulate peroxisome biogenesis during proteotoxic stress","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; Connaught Fund; Children’s Hospital of Wisconsin Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Seattle Children's Research Institute; University of Texas Southwestern Medical Center; Ohio State University; U.S. Department of Health and Human Services","keywords":"Peroxisome; Biogenesis; Endoplasmic reticulum; Proteostasis; Unfolded protein response; Cellular compartment; Cytosol; Organelle biogenesis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009358148,0.0003393288,0.0002016126,0.0001930357,0.0001916115,0.0003209549,0.0001083964,0.0002463862,0.001225065],"category_scores_gemma":[0.00006871463,0.0001112747,0.0002200824,0.0001284436,0.0002879166,0.0001992053,0.0002807225,0.0003538791,0.0003225595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002780819,"about_ca_system_score_gemma":0.000193238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005397397,"about_ca_topic_score_gemma":0.001081282,"domain_scores_codex":[0.999898,0.00001698616,0.000008153611,0.00001783006,0.00002224186,0.00003677078],"domain_scores_gemma":[0.9999268,0.00000644689,0.00002676801,0.000008176849,0.00001085672,0.00002084522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002277673,0.000008943424,0.0001638356,0.00002742396,0.000003574513,0.00005700397,0.000008266095,0.00006133641,0.9982943,0.0001022859,0.00004744206,0.000997853],"study_design_scores_gemma":[0.00001362301,0.0002300675,0.02087378,0.000008254953,0.00001515728,0.00031074,0.00007415994,0.0005978411,0.9758039,0.0001664317,0.001897007,0.0000091177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871073,0.0049946,0.003654258,0.0003079247,0.000081412,0.00005505429,0.0007431011,0.0001958936,0.002860403],"genre_scores_gemma":[0.9944326,0.001399271,0.001020734,0.0001065772,0.00001237836,0.00004165722,0.0005798101,0.0000148527,0.002392173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225065,"threshold_uncertainty_score":0.004098237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008799460176099299,"score_gpt":0.2642776854164668,"score_spread":0.2554782252403675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}