{"id":"W4416807566","doi":"10.1016/j.ebiom.2025.106036","title":"Early lymph node T follicular helper cell signalling hub drives influenza vaccine response in an ancestrally diverse cohort","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"H2020 Marie Skłodowska-Curie Actions; Wellcome Trust; NIHR Oxford Biomedical Research Centre; NIHR Imperial Biomedical Research Centre; Chan Zuckerberg Initiative; Medical Research Council; Janssen Biotech; Royal Society; National Institute for Health and Care Research; Horizon 2020 Framework Programme; UK Research and Innovation; Silicon Valley Community Foundation","keywords":"Cohort; Vaccination; Cohort study; Influenza vaccine; Follicular phase; Lymph node; Immune system; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002372943,0.0001362126,0.0002205754,0.0001996591,0.000321772,0.0004479551,0.000154398,0.000214084,0.001688606],"category_scores_gemma":[0.0004840809,0.0001240183,0.0001165327,0.0001545722,0.0003046557,0.0002340488,0.0003434681,0.0003633614,0.0003251735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001661766,"about_ca_system_score_gemma":0.0001390236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008911178,"about_ca_topic_score_gemma":0.0008606272,"domain_scores_codex":[0.9998612,0.00002666447,0.000005982443,0.00006440314,0.00001148309,0.00003029941],"domain_scores_gemma":[0.9998322,0.0000266036,0.00003938223,0.00002578128,0.00001889632,0.00005720313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001572081,0.0001560779,0.9077778,0.00003374333,0.00005149568,0.0005499034,0.001277261,0.0001213668,0.08175568,0.0001733321,0.0002018092,0.00632944],"study_design_scores_gemma":[0.000007516331,0.0007396993,0.9946328,0.000007010308,0.00002268498,0.0009630753,0.0009038511,0.0001953214,0.001663792,0.0001514695,0.0007070468,0.000005671568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996068,0.0000545572,0.00009009213,0.00000959987,0.000001292609,0.000003666147,0.0001050332,0.000001473632,0.0001274988],"genre_scores_gemma":[0.9994702,0.00004041545,0.0001006456,0.0000180368,0.000003831341,0.0000101277,0.0001354166,0.000002135126,0.0002192708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001688606,"threshold_uncertainty_score":0.005648911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04163862088269431,"score_gpt":0.3667536032606305,"score_spread":0.3251149823779362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}