{"id":"W4416808330","doi":"10.1002/acr2.70139","title":"A Guide for Initiating and Managing Chimeric Antigen Receptor T Cell Therapy Clinical Trials in Autoimmune Rheumatic Diseases","year":2025,"lang":"en","type":"article","venue":"ACR Open Rheumatology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Clinical trial; Chimeric antigen receptor; Autoimmunity; Translational research; Immune system; Cell therapy; Rheumatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02537111,0.002438063,0.002678965,0.006307893,0.001379929,0.009460938,0.004283638,0.008843722,0.04027102],"category_scores_gemma":[0.05245053,0.002559265,0.002453856,0.004509726,0.001968621,0.006289782,0.003685788,0.01361389,0.05567367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002804939,"about_ca_system_score_gemma":0.01337458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002987282,"about_ca_topic_score_gemma":0.009754051,"domain_scores_codex":[0.9791393,0.01191558,0.004039242,0.0008772466,0.003472691,0.0005557791],"domain_scores_gemma":[0.9436445,0.02947018,0.00663971,0.003091473,0.01032971,0.006824491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001728622,0.0004024295,0.0006588113,0.001281172,0.00007301739,0.0009078079,0.0004017581,0.001198937,0.001111431,0.007383658,0.6271951,0.3592131],"study_design_scores_gemma":[0.0003159452,0.000274925,0.001281946,0.002964782,0.00005564577,0.001436024,0.0002024044,0.001110749,0.0003480104,0.01222028,0.9797072,0.00008222164],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.00242837,0.09296804,0.3813617,0.2742148,0.01718349,0.01463011,0.009928166,0.02890263,0.1783827],"genre_scores_gemma":[0.00653106,0.06651688,0.7149515,0.09371709,0.009198004,0.01896462,0.005199998,0.00367092,0.08124998],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.04027102,"threshold_uncertainty_score":0.13472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.128755947908628,"score_gpt":0.4867129642659138,"score_spread":0.3579570163572858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}