{"id":"W4416812434","doi":"10.1016/j.isci.2025.114281","title":"Spatial single-cell profiling identifies protein kinase Cδ-expressing microglia with anti-tumor function in glioblastoma","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Institute of Cancer Research; University of Calgary; University of Alberta","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canadian Cancer Society; Alberta Cancer Foundation","keywords":"Microglia; Immune system; Transcriptome; Kinase; Function (biology); Glioblastoma; Inflammation; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238033,0.0001871798,0.0001516005,0.0003791268,0.0003820845,0.0004061664,0.0003183178,0.00003638508,0.00002499587],"category_scores_gemma":[0.0002728517,0.0001672003,0.00003266762,0.001098803,0.0001860775,0.0006940929,0.0001050477,0.0001944156,0.00004107242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004499191,"about_ca_system_score_gemma":0.0001399307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001319571,"about_ca_topic_score_gemma":0.00006390577,"domain_scores_codex":[0.9979722,0.000167654,0.0003320759,0.0007502475,0.0004295015,0.0003483282],"domain_scores_gemma":[0.9993386,0.00006579555,0.0001659029,0.0003055541,0.00006162798,0.00006246659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007894301,0.0001036976,0.0001715706,0.00003623389,2.549218e-7,0.00006443951,0.00006946019,0.0004867001,0.9970418,0.001031711,0.00001973354,0.0008954122],"study_design_scores_gemma":[0.0005005213,0.0001854219,0.0002409803,0.0001139991,0.000003895957,0.00001346066,0.00005319951,0.006823459,0.9914429,0.000253819,0.0001968394,0.0001715703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716271,0.00001862199,0.02594515,0.0002288141,0.0005060305,0.0006229411,0.000003676103,0.0001543137,0.0008934143],"genre_scores_gemma":[0.9971896,0.00000124862,0.0006572007,0.0006339567,0.00003388942,0.0000552495,5.718787e-7,0.00001451429,0.001413736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02556259,"threshold_uncertainty_score":0.6818231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817988429652205,"score_gpt":0.2360663750097921,"score_spread":0.2178864907132701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}