{"id":"W4416815778","doi":"10.1016/j.jcf.2025.11.016","title":"Elexacaftor/tezacaftor/ivacaftor is associated with long-term reduction in use of chronic respiratory therapies in cystic fibrosis","year":2025,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis; Respiratory system; Respiratory disease; Reduction (mathematics); Tonicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001067695,0.0004413781,0.001420778,0.001870678,0.00007798354,0.00008783927,0.0003669219,0.0003127681,0.0002079784],"category_scores_gemma":[0.002718659,0.0003580945,0.0002971783,0.002075501,0.0004306917,0.0007974798,0.00009760753,0.000978765,0.00000580912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001955743,"about_ca_system_score_gemma":0.00147289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001025393,"about_ca_topic_score_gemma":0.00003208002,"domain_scores_codex":[0.9952227,0.0004456403,0.001863573,0.0004671919,0.001277905,0.0007229355],"domain_scores_gemma":[0.9959378,0.001414865,0.001024952,0.0005669457,0.0008122598,0.0002431464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01364157,0.001761606,0.5295158,0.002170661,0.0009696922,0.0004586169,0.0002818684,0.001390135,0.4320664,0.00005104686,0.003962209,0.01373039],"study_design_scores_gemma":[0.007515097,0.005051696,0.9373519,0.01513277,0.0003899795,0.0001430976,0.0001796572,0.0003574424,0.03087534,0.0001474135,0.002487202,0.0003684417],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885589,0.009422075,0.0008605049,0.0002341247,0.00009641596,0.0007002409,0.0000563347,0.0000273724,0.00004404981],"genre_scores_gemma":[0.9933252,0.0003619952,0.00542189,0.0001185334,0.0001930269,0.00004853159,0.00001399407,0.00006150828,0.0004552972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4078361,"threshold_uncertainty_score":0.9998871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182165227017158,"score_gpt":0.3117406231011932,"score_spread":0.2899189708310216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}