{"id":"W4416818715","doi":"10.1016/j.toxrep.2025.102176","title":"Safety assessment and gastrointestinal tolerance of a novel highly bioavailable turmeric extract formulation: A randomised, double-blind, placebo controlled clinical trial","year":2025,"lang":"en","type":"article","venue":"Toxicology Reports","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Intertek (Canada)","funders":"Givaudan","keywords":"Placebo; Clinical trial; Urinalysis; Tolerability; Adverse effect; Stomach; Gastrointestinal tract; Drug tolerance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001442903,0.0001992849,0.0006888761,0.00008028565,0.0001028032,0.00001670887,0.0001246371,0.0002626852,0.00005805031],"category_scores_gemma":[0.0004245756,0.0001735822,0.0002094002,0.0001916211,0.0003447099,0.000006570065,0.000132468,0.000198839,0.000001091122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003018265,"about_ca_system_score_gemma":0.0006132317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000120879,"about_ca_topic_score_gemma":0.00002003903,"domain_scores_codex":[0.9974346,0.0001014588,0.001449719,0.0005904552,0.0001575147,0.0002662264],"domain_scores_gemma":[0.9981768,0.0003053381,0.0007212897,0.0004901286,0.0001778346,0.0001286247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.700361,0.00180318,0.008336473,0.00004346407,0.0003005559,0.00003416349,0.000007812846,0.00005428318,0.2844636,0.0006216696,0.001808172,0.00216565],"study_design_scores_gemma":[0.9601473,0.0018746,0.007204937,0.0000560042,0.0002781966,0.0006653721,0.00001829917,0.001128908,0.006902544,0.0001302052,0.02131989,0.0002737372],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527641,0.0002597246,0.03916949,0.0009366063,0.0004102176,0.003202897,0.00001282979,0.00002296388,0.003221168],"genre_scores_gemma":[0.9885258,0.00004890679,0.008787392,0.0002355078,0.0002291055,0.0006199469,0.0001260953,0.00001222819,0.001414991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2775611,"threshold_uncertainty_score":0.7078478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03862886737766055,"score_gpt":0.3751730881711288,"score_spread":0.3365442207934682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}