{"id":"W4416820994","doi":"10.1038/s41467-025-66805-6","title":"Development of ACE2-tropic-betacoronavirus therapeutics for future pandemic preparedness","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of General Medical Sciences","keywords":"Pandemic; Neutralization; Monoclonal antibody; Coronavirus disease 2019 (COVID-19); Epitope; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Antibody; Preparedness","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002851238,0.0003697112,0.0001874954,0.0001090167,0.00009871621,0.0003872236,0.0001946932,0.0003537255,0.001437571],"category_scores_gemma":[0.0001092536,0.00008584383,0.0001807128,0.00004989287,0.0001641927,0.0002737989,0.0001404023,0.0006555889,0.0003299441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625195,"about_ca_system_score_gemma":0.0002491726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002528727,"about_ca_topic_score_gemma":0.0007526793,"domain_scores_codex":[0.9999108,0.00001597124,0.000004734863,0.00001465451,0.0000287781,0.00002509319],"domain_scores_gemma":[0.9999402,0.000007242187,0.00001665581,0.000006036422,0.00001248674,0.00001730527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001375454,0.0001389284,0.0003385882,0.0001061351,0.00001655514,0.0001002078,0.00002840394,0.0003537266,0.9703088,0.0007460795,0.0004694619,0.0272556],"study_design_scores_gemma":[0.0002462027,0.005480493,0.003996111,0.00007060119,0.00005718139,0.001806007,0.00007264855,0.003443759,0.9344527,0.0006804543,0.04967615,0.00001766183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9131491,0.03373631,0.02661877,0.0019221,0.0004822988,0.0003493991,0.0003990774,0.0003224831,0.02302036],"genre_scores_gemma":[0.9773607,0.007911793,0.009732452,0.0007447541,0.00009552136,0.00006426237,0.0002820687,0.00001744908,0.003790914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001437571,"threshold_uncertainty_score":0.004809141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08655490691253236,"score_gpt":0.4439427832490376,"score_spread":0.3573878763365053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}