{"id":"W4416821081","doi":"10.1101/2025.11.23.690026","title":"A systematic interactome of SET1C expands its functional landscape and identifies candidate regulatory connections","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Interactome; Chromatin; RNA splicing; Histone; Spliceosome; Corepressor; Saccharomyces cerevisiae; Ribonucleoprotein; Transcription (linguistics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819026,0.0003261023,0.0003664421,0.001074037,0.0003253049,0.0004754272,0.0002900801,0.0003389418,0.004202401],"category_scores_gemma":[0.0004175042,0.0001780683,0.0003941119,0.000762684,0.0002037348,0.0002513962,0.0004350197,0.0004248935,0.0006691326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004608549,"about_ca_system_score_gemma":0.0001759766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006513119,"about_ca_topic_score_gemma":0.001467242,"domain_scores_codex":[0.999744,0.00002346288,0.00001781457,0.00009600029,0.00008235598,0.0000364667],"domain_scores_gemma":[0.9996639,0.0001219582,0.00006616946,0.00005445111,0.00004169727,0.00005184644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003561459,0.00002929022,0.01757134,0.0002027835,0.0000918107,0.0003824711,0.0000481237,0.0007268912,0.9698272,0.000472327,0.0005217708,0.009769811],"study_design_scores_gemma":[0.00005581813,0.0002138517,0.4124005,0.00008758733,0.0004496675,0.004719236,0.0002239348,0.02605127,0.5327855,0.001622129,0.02133796,0.00005255358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865991,0.002043594,0.003797864,0.0001986531,0.00001510405,0.00001432828,0.00447661,0.0002212022,0.002633718],"genre_scores_gemma":[0.990294,0.0004403659,0.003037285,0.00008860451,0.000008843336,0.00001724318,0.005053006,0.00004654694,0.001014245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004202401,"threshold_uncertainty_score":0.01405841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007536695998633754,"score_gpt":0.2193194801346799,"score_spread":0.2117827841360461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}