{"id":"W4416824270","doi":"10.1111/jipb.70081","title":"Phosphorylation fine‐tunes ceramide synthase activity and stability to modulate sphingolipid biosynthesis and immune responses","year":2025,"lang":"en","type":"article","venue":"Journal of Integrative Plant Biology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"","keywords":"Sphingolipid; Ceramide synthase; Ceramide; Phosphorylation; Serine; Biosynthesis; Kinase; Lipid signaling; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268351,0.0004056277,0.0001926975,0.0001491755,0.0001339921,0.0003818736,0.0001739688,0.0001914952,0.001148626],"category_scores_gemma":[0.00007347354,0.0001312473,0.0001387362,0.0001124081,0.00019742,0.0003221922,0.0002934621,0.0002982566,0.0003271414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003637706,"about_ca_system_score_gemma":0.0001897407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003350529,"about_ca_topic_score_gemma":0.0006851315,"domain_scores_codex":[0.9999316,0.000007994695,0.000004421478,0.00002090955,0.00001574466,0.0000193129],"domain_scores_gemma":[0.9999449,0.000006134875,0.00001907953,0.00000628306,0.000006624031,0.00001685477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005286898,0.000005535052,0.000220708,0.0000171236,0.000002541945,0.00001801793,0.000003846984,0.00005887216,0.9987674,0.00007715792,0.00001954109,0.0007564946],"study_design_scores_gemma":[0.00002963954,0.0001064098,0.01688252,0.000007477079,0.00002337063,0.0002324013,0.00003907579,0.003063456,0.9759093,0.0002247739,0.003469778,0.00001177407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906139,0.00305379,0.003695456,0.0001246158,0.0000392089,0.00001914752,0.0002385805,0.0001145726,0.002100749],"genre_scores_gemma":[0.9969597,0.0008179079,0.0008837539,0.00003594476,0.000009283785,0.000008331779,0.0001368154,0.00001617669,0.0011321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148626,"threshold_uncertainty_score":0.003842592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01198946457617248,"score_gpt":0.2681283828259096,"score_spread":0.2561389182497371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}