{"id":"W4416827100","doi":"10.1136/jitc-2025-013214","title":"JAK inhibitors for the treatment of life-threatening and refractory immune-related adverse events secondary to immune checkpoint inhibitors: a prospective cohort study","year":2025,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; St Mary's Hospital Centre; Jewish General Hospital; McGill University Health Centre","funders":"","keywords":"Adverse effect; Prospective cohort study; Refractory (planetary science); Immune checkpoint; Cohort study; Clinical trial; Immune system; Safety profile","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001237672,0.0005342756,0.0006952235,0.0006625901,0.0008485297,0.001296574,0.0005073093,0.0006382776,0.002687575],"category_scores_gemma":[0.002122044,0.0005897172,0.001511961,0.00120786,0.0002608703,0.0006676904,0.0005803398,0.001369743,0.0004776407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006479548,"about_ca_system_score_gemma":0.001109444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008262039,"about_ca_topic_score_gemma":0.008651164,"domain_scores_codex":[0.9990824,0.0001697536,0.00008403654,0.0003421222,0.0001528817,0.0001686087],"domain_scores_gemma":[0.9981268,0.0002124179,0.0007424635,0.0002558137,0.0002356105,0.0004269541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001578715,0.0001784995,0.9948269,0.00003645874,0.000701194,0.0002359089,0.00004598082,0.00004926473,0.0002763766,0.0000426871,0.0005080705,0.001519944],"study_design_scores_gemma":[0.0005159415,0.0008684074,0.995374,0.00003243844,0.0006764089,0.0008954679,0.0001994933,0.0003611394,0.00008287255,0.00004897628,0.0009239773,0.00002094199],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953296,0.001409636,0.0002520232,0.0000991154,0.00003192156,0.0001194878,0.002069615,0.000008598064,0.0006799913],"genre_scores_gemma":[0.9970803,0.0006109691,0.0001745861,0.0001437903,0.00005021491,0.00007221029,0.001533634,0.000007392867,0.0003268651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008262039,"threshold_uncertainty_score":0.01642787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101398185958649,"score_gpt":0.3138124658552414,"score_spread":0.3027984839956548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}