{"id":"W4416827190","doi":"10.1038/s41398-025-03776-8","title":"Integrative neuroimmunology reveals leukocyte-expressing PAX6 as a critical predictor of major depressive disorder","year":2025,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Israel Science Foundation; Ministério da Ciência, Tecnologia e Inovação; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Neuroimmunology; Transcriptome; Major depressive disorder; Biomarker; Immune system; Schizophrenia (object-oriented programming); PAX6; DISC1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574199,0.0001645047,0.0002179414,0.000421376,0.0001480426,0.0002859712,0.0001624583,0.0001907902,0.001049025],"category_scores_gemma":[0.0003848442,0.0001017673,0.0002505718,0.0004425434,0.0001999208,0.0000968837,0.0003384646,0.0002278062,0.0001062173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238764,"about_ca_system_score_gemma":0.000111682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149204,"about_ca_topic_score_gemma":0.001864543,"domain_scores_codex":[0.9998299,0.00004155507,0.00001240648,0.00007422497,0.00002027816,0.00002163253],"domain_scores_gemma":[0.9998272,0.00004039812,0.00006918582,0.00002375824,0.00001548259,0.00002404666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009798084,0.00002938884,0.9483887,0.00004153738,0.0002615485,0.0001965,0.0001358641,0.0004014548,0.03533318,0.0001542036,0.0002465612,0.0138312],"study_design_scores_gemma":[0.000008173883,0.00006855346,0.9974529,0.000005447426,0.00007593461,0.0003190041,0.00008662681,0.0008564694,0.0007981482,0.0001255975,0.0001999989,0.000003040042],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989868,0.0002311988,0.0003016854,0.00003209307,0.000002318533,0.000003115298,0.0002613116,0.000005012933,0.0001764622],"genre_scores_gemma":[0.9993367,0.00007617624,0.0002361887,0.000018947,0.000002876156,0.000002975179,0.0002578464,0.00000196007,0.00006630974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149204,"threshold_uncertainty_score":0.003509283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562705757200335,"score_gpt":0.3074876075805923,"score_spread":0.291860550008589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}