{"id":"W4416834937","doi":"10.18331/brj2025.12.4.5","title":"Cell factories and transcription factor engineering for bioproducts: the case of Candida glabrata for α-ketoglutarate production","year":2025,"lang":"en","type":"article","venue":"Biofuel Research Journal","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fundamental Research Funds for the Central Universities; Natural Science Foundation of Jiangsu Province; Government of Jiangsu Province","keywords":"Transcription factor; Citric acid cycle; Metabolic engineering; Candida glabrata; Metabolic pathway; Glycolysis; Flux (metallurgy); Transcription (linguistics); Metabolic flux analysis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003035603,0.0007487711,0.0003479835,0.0002810238,0.0002286551,0.0008084968,0.0003039887,0.0005451675,0.0006139164],"category_scores_gemma":[0.0002522579,0.0001563925,0.0005736215,0.0005226419,0.0003084616,0.0003429943,0.0003355291,0.0008528092,0.0003842019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005932008,"about_ca_system_score_gemma":0.0004898398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001979822,"about_ca_topic_score_gemma":0.002074597,"domain_scores_codex":[0.9997947,0.00002556191,0.00002072042,0.00005121042,0.00005985444,0.00004797936],"domain_scores_gemma":[0.9999288,0.00001355884,0.00001432735,0.00001266233,0.00001575444,0.0000148491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005472788,0.0000339318,0.0002050104,0.0001150997,0.00001026162,0.0001217044,0.00002537891,0.0007929467,0.9912937,0.000806087,0.00008337774,0.006457715],"study_design_scores_gemma":[0.0000122246,0.0001472206,0.0006268368,0.00001581715,0.00003027256,0.000168566,0.00004446071,0.002195046,0.9873058,0.0002501408,0.00918675,0.00001687812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8845313,0.009454233,0.09741109,0.0008225546,0.0002494791,0.0002521768,0.0008547074,0.0006030502,0.00582144],"genre_scores_gemma":[0.9042357,0.006240174,0.0830261,0.0001657168,0.00002607929,0.000160776,0.001019289,0.0001339327,0.004992277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001979822,"threshold_uncertainty_score":0.004303992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02897077619495902,"score_gpt":0.3236205027347563,"score_spread":0.2946497265397973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}