{"id":"W4416837248","doi":"10.1007/s40290-025-00593-8","title":"Considerations for Biosimilar Adoption in Pediatrics: A Scoping Review","year":2025,"lang":"en","type":"review","venue":"Pharmaceutical Medicine","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Clinical Evaluative Sciences; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biosimilar; Pharmacovigilance; New product development; Product (mathematics); Key (lock); MEDLINE; Drug development","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001768762,0.0004612886,0.002832561,0.0004121802,0.000109748,0.000008017783,0.0002158101,0.0006518074,0.00216077],"category_scores_gemma":[0.00676569,0.0003151144,0.0004027376,0.0006807882,0.000336428,0.00003577565,0.0001008704,0.0009210979,0.00004643233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009374871,"about_ca_system_score_gemma":0.000489741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002749554,"about_ca_topic_score_gemma":0.000004884405,"domain_scores_codex":[0.9965501,0.0008171505,0.001432445,0.0006175949,0.00006604287,0.0005166776],"domain_scores_gemma":[0.9920627,0.007175566,0.0002478869,0.0003136351,0.0001232809,0.00007685589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001288762,0.00008578577,0.000001487399,0.3512535,0.0001064299,0.000008316328,0.000005764948,1.614582e-8,0.000006374902,0.001322216,0.02648712,0.6207101],"study_design_scores_gemma":[0.0006791273,0.00007637352,2.733902e-7,0.363548,0.003346437,0.00002993091,0.000002656469,0.000001463962,0.000006497908,0.0002376377,0.6318633,0.0002083733],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[1.034838e-8,0.9873013,0.0005574856,0.005450537,0.001244622,0.00426941,0.0001123633,0.00005278296,0.00101152],"genre_scores_gemma":[4.95729e-7,0.9910878,0.001157354,0.006303944,0.0002518658,0.0006744149,0.0001612516,0.00002352958,0.0003393231],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6205018,"threshold_uncertainty_score":0.9999301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2351960777849705,"score_gpt":0.5185248198969498,"score_spread":0.2833287421119793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}