{"id":"W4416838085","doi":"10.1101/2025.11.29.691178","title":"Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent <i>S</i> -Nitroso Transfer","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Proteome; Interactome; Proteomics; Regulator; Adaptation (eye); Red blood cell; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009969627,0.0002272235,0.0001451151,0.0001349971,0.0001499632,0.0003039927,0.0001254852,0.0002755362,0.0009284675],"category_scores_gemma":[0.00007979596,0.0001087738,0.0002224908,0.00007976613,0.0001631947,0.0001421236,0.0002624079,0.0002872969,0.0003524551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002757238,"about_ca_system_score_gemma":0.0001276234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007768309,"about_ca_topic_score_gemma":0.0008483701,"domain_scores_codex":[0.9999052,0.00001047789,0.000005117524,0.00004231176,0.00002176358,0.00001505272],"domain_scores_gemma":[0.9999242,0.000006197758,0.00003544749,0.000007340139,0.000008468171,0.00001840306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005737934,0.000003979222,0.0009431667,0.000007509805,0.00000379129,0.00003101488,0.00001137723,0.00002672947,0.9983393,0.00006416935,0.00003493841,0.0004766044],"study_design_scores_gemma":[0.0000128859,0.0001305818,0.1275997,0.0000121165,0.00003370339,0.0008674936,0.00008540764,0.004727751,0.86244,0.0003337202,0.003744475,0.00001220373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949509,0.0003573954,0.003577815,0.0001114152,0.00001149189,0.000004762859,0.0003791406,0.00008092726,0.000526105],"genre_scores_gemma":[0.995111,0.0001563853,0.002294912,0.000115871,0.000006790634,0.000009045957,0.0007854719,0.00003631641,0.001484222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009284675,"threshold_uncertainty_score":0.003105998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007121385838771413,"score_gpt":0.2024088075865618,"score_spread":0.1952874217477903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}