{"id":"W4416840488","doi":"10.1021/acs.orglett.5c04616","title":"Glyoxylate Sulfonyl Hydrazone Enables a Scalable Approach to Reformatsky-Type Products from Aliphatic Alcohols via Photocatalytic HAT","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Sulfur-Based Synthesis Techniques","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"HORIZON EUROPE European Innovation Council; H2020 Marie Skłodowska-Curie Actions; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Sulfonyl; Photocatalysis; Hydrazone; Hydrazide; Glyoxylate cycle; Catalysis; Decomposition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003547089,0.0005347992,0.0006195377,0.0002599816,0.0001973879,0.0001879856,0.001035093,0.0002457913,0.000549568],"category_scores_gemma":[0.0003755732,0.0005108119,0.0001139224,0.001160711,0.0001284868,0.0003623787,0.000323311,0.0003803083,0.0004916145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008161665,"about_ca_system_score_gemma":0.0002822193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005918134,"about_ca_topic_score_gemma":0.000014678,"domain_scores_codex":[0.9969782,0.0000569956,0.0006347802,0.001048195,0.0004729802,0.0008088461],"domain_scores_gemma":[0.9975376,0.0001708784,0.0001834109,0.001819825,0.0001030421,0.00018528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009073487,0.0002011193,0.0002382912,0.0003200672,0.0001946059,0.00001727792,0.0004330554,0.00001137388,0.9789477,0.00001773229,0.01802895,0.001499097],"study_design_scores_gemma":[0.000535755,0.00001715177,0.00005898604,0.0003037303,0.0001526501,0.000009324287,0.0001187943,0.0002484025,0.989902,0.0002052808,0.007902231,0.0005456464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827054,0.0003014699,0.002218246,0.004703305,0.0002004884,0.0007204356,0.00002803853,0.0009515425,0.00817103],"genre_scores_gemma":[0.9839072,0.00002582366,0.007278933,0.006245356,0.0002088778,0.0002116059,0.0002053233,0.0001387508,0.001778089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01095435,"threshold_uncertainty_score":0.9997343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140941693951618,"score_gpt":0.2225506750239707,"score_spread":0.2111412580844545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}