{"id":"W4416841363","doi":"10.1007/s40268-025-00530-9","title":"Safety, Tolerability and Pharmacokinetics of a High-Dose, Rapid-Infusion Monoclonal Antibody: Phase I Results for Intravenous Sotrovimab 3000 mg","year":2025,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"GlaxoSmithKline Biologicals; Vir Biotechnology","keywords":"Pharmacokinetics; Tolerability; Monoclonal antibody; Phase (matter); Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041121,0.0007068986,0.0007771423,0.0002226841,0.0001969111,0.0005757292,0.0006259659,0.0008031811,0.001723633],"category_scores_gemma":[0.0009866689,0.000308857,0.0007016038,0.0001740493,0.0004742373,0.0004688094,0.000133414,0.001685477,0.0004732228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004572677,"about_ca_system_score_gemma":0.0005312233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00039392,"about_ca_topic_score_gemma":0.0003978223,"domain_scores_codex":[0.9996749,0.0001557605,0.00001616167,0.00004268111,0.00005904885,0.00005145522],"domain_scores_gemma":[0.9994282,0.0001143887,0.0002086062,0.00005852172,0.00005518766,0.0001350298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2360135,0.0499821,0.01050746,0.0007084573,0.0007712268,0.000360291,0.0005000906,0.004397095,0.549551,0.0002170318,0.002535005,0.1444567],"study_design_scores_gemma":[0.1314066,0.7348071,0.04329658,0.00006815675,0.0006311262,0.001271893,0.00008654461,0.005812259,0.07817993,0.0002131714,0.004165082,0.00006152994],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972791,0.000613703,0.0009905627,0.0001093471,0.00001871431,0.000424627,0.0002160288,0.00005449628,0.000293506],"genre_scores_gemma":[0.9955539,0.0006245575,0.001947851,0.0001741193,0.00005361439,0.0004399473,0.0005030032,0.00002999783,0.0006730654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001723633,"threshold_uncertainty_score":0.005766153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01954396181163665,"score_gpt":0.3693013937195685,"score_spread":0.3497574319079318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}