{"id":"W4416842637","doi":"10.1016/j.exphem.2025.104970","title":"3029 – MODELING EFFICIENT HSC DEVELOPMENT FROM HUMAN PLURIPOTENT STEM CELLS","year":2025,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Embryonic stem cell; Induced pluripotent stem cell; Haematopoiesis; Stem cell; Transplantation; Progenitor cell; Mesoderm; Regenerative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001535955,0.0002874792,0.0003257969,0.0001217864,0.0002733405,0.00003258573,0.000440285,0.0002428249,0.00009873102],"category_scores_gemma":[0.000004202753,0.0002904693,0.000116353,0.0001087649,0.0001070207,0.000003031132,0.0006655472,0.0001515956,0.0001409151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226829,"about_ca_system_score_gemma":0.0001485136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005861694,"about_ca_topic_score_gemma":0.0000161974,"domain_scores_codex":[0.9978399,0.0001127207,0.0004873756,0.0007608653,0.0002543205,0.0005448103],"domain_scores_gemma":[0.9992048,0.00001567308,0.00007109968,0.0005146064,0.00005983275,0.0001339689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009151571,0.0003868865,0.0001821343,0.0000282747,0.0001207217,0.00002797467,0.0001896619,0.001695116,0.9944339,0.001670013,0.0009190018,0.0002547452],"study_design_scores_gemma":[0.000896862,0.00008241602,0.00002492491,0.00004457357,0.000007752696,0.00001178558,0.0005627865,0.004775916,0.9874002,0.00002535928,0.00590451,0.0002628949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800164,0.01009807,0.006008422,0.00007707158,0.0004398237,0.0004117388,0.00001021442,0.00004151911,0.002896704],"genre_scores_gemma":[0.9960183,0.00001751128,0.001266254,0.0001875901,0.00005624839,0.000124807,0.0001185736,0.00003070898,0.002180022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01600185,"threshold_uncertainty_score":0.9999548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914464114576542,"score_gpt":0.2967831811916203,"score_spread":0.2776385400458549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}