{"id":"W4416842711","doi":"10.1016/j.exphem.2025.105159","title":"3218 – LYL1 IS CRITICAL FOR ADULT HEMATOPOIETIC STEM CELL-DERIVED B- AND T-LYMPHOPOIESIS","year":2025,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba","funders":"","keywords":"Haematopoiesis; Progenitor cell; Transcription factor; Stem cell; Conditional gene knockout; Transplantation; Progenitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008061388,0.0001769853,0.0002413544,0.00006690046,0.0001780475,0.00002788645,0.0002275727,0.0002404132,0.00006785133],"category_scores_gemma":[0.0001227266,0.0001756718,0.00008946427,0.0001068754,0.0005395579,0.000004593287,0.0002737059,0.00005432929,0.00002261837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002929554,"about_ca_system_score_gemma":0.0001060047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009819292,"about_ca_topic_score_gemma":0.000003417486,"domain_scores_codex":[0.9986368,0.00004592891,0.0002598836,0.0005314612,0.0001208369,0.0004051167],"domain_scores_gemma":[0.9991612,0.0001308472,0.00003447013,0.000352925,0.000137951,0.0001825746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001555745,0.0003545366,0.0001792819,0.000174654,0.00005544882,0.000004165481,0.0001583143,3.728039e-8,0.8610641,0.08907446,0.04810013,0.0006793362],"study_design_scores_gemma":[0.0009955242,0.0002197054,0.00004171759,0.00002007925,0.00001016258,0.00004324106,0.001455901,0.00007175981,0.9822251,0.0007787307,0.01398196,0.0001561404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9115718,0.03751052,0.02310771,0.01688281,0.0003394954,0.001826857,0.0001672393,0.00009867478,0.008494892],"genre_scores_gemma":[0.9933662,0.0001177002,0.002057254,0.002832817,0.00004200376,0.000747191,0.0000523981,0.00002124155,0.0007631737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.121161,"threshold_uncertainty_score":0.7163687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007794669999021,"score_gpt":0.3299164519037963,"score_spread":0.3198385052038061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}