{"id":"W4416850755","doi":"10.1038/s41593-025-02113-y","title":"Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling","year":2025,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; Centre Hospitalier de l’Université de Montréal; University of Calgary; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Multiple Sclerosis Society of Canada; Fondation Brain Canada","keywords":"Neurodegeneration; Multiple sclerosis; Microglia; Oxidative stress; Central nervous system; Lesion; Chronic stress; Pathogenesis; Neuroprotection","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000319683,0.001097318,0.0004080666,0.001212912,0.0003705277,0.0007373653,0.0003711947,0.001068629,0.002153045],"category_scores_gemma":[0.000167761,0.0004695526,0.0006199045,0.0004800841,0.0007967223,0.0006030144,0.0004204123,0.002011986,0.0006828106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000588689,"about_ca_system_score_gemma":0.0004046564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001031571,"about_ca_topic_score_gemma":0.001945224,"domain_scores_codex":[0.9995345,0.00005355108,0.00006146071,0.0001353995,0.0001144284,0.0001007629],"domain_scores_gemma":[0.9995182,0.00002754616,0.000241406,0.00004338064,0.00004976656,0.0001196782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005902502,0.0001261134,0.0005637428,0.00006916474,0.00002681027,0.0003552293,0.00005239228,0.00007479718,0.9970444,0.0002577946,0.00009385928,0.000745318],"study_design_scores_gemma":[0.0001599759,0.0008280286,0.01366758,0.00006851798,0.0001680226,0.001711463,0.0002855246,0.001728871,0.9773698,0.0006045011,0.003387081,0.0000205619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930326,0.001197994,0.002875881,0.0003257699,0.00008347398,0.00004338043,0.001023115,0.0001798619,0.001237904],"genre_scores_gemma":[0.988984,0.001215895,0.002712197,0.0001612701,0.00003328505,0.00009615628,0.0006949981,0.00006933939,0.006032875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002153045,"threshold_uncertainty_score":0.007202625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02991754835521751,"score_gpt":0.2703611359448562,"score_spread":0.2404435875896387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}