{"id":"W4416852000","doi":"10.1038/d43747-025-00111-4","title":"The year of the bispecific in oncology and beyond","year":2025,"lang":"en","type":"article","venue":"Biopharma Dealmakers","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Bispecific antibody; Quarter (Canadian coin); Antibody therapy; Radiation oncology; Momentum (technical analysis)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002512014,0.00006044232,0.0001322073,0.00006309481,0.00008752653,0.000006720514,0.000112366,0.00004566257,0.0000345212],"category_scores_gemma":[0.00005267826,0.00003005275,0.00004960208,0.0002876302,0.0003410188,0.00001083917,0.0001067774,0.0001887961,0.000008592656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000386007,"about_ca_system_score_gemma":0.0001544957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009076766,"about_ca_topic_score_gemma":0.00005363676,"domain_scores_codex":[0.9993511,0.0000636976,0.000164917,0.0001088267,0.0001443728,0.0001670435],"domain_scores_gemma":[0.9995255,0.0002203491,0.00003029359,0.0001442833,0.0000377105,0.0000418553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003854071,0.000334401,0.5817443,0.0003526846,0.0002809129,0.0001194062,0.0007614434,0.000002582444,0.09235609,0.06165382,0.0773824,0.1811579],"study_design_scores_gemma":[0.001232175,0.0000936191,0.3735646,0.00004431101,0.00001883869,0.00001741717,0.0005077997,0.00007367819,0.007862188,0.0004211878,0.6161218,0.00004246561],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9291083,0.002762145,6.789444e-7,0.02556466,0.000233179,0.0002615566,0.000007591581,0.000005260183,0.04205663],"genre_scores_gemma":[0.9887575,0.001796471,0.00005446647,0.0008478195,0.00004068362,0.00001012992,0.00000133393,0.000004365645,0.008487249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5387393,"threshold_uncertainty_score":0.1256498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538064952659011,"score_gpt":0.3433365801308608,"score_spread":0.3279559306042707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}