{"id":"W4416853804","doi":"10.1002/alz.70957","title":"CSF markers of vascular injury correlate with tau and cognitive decline in early Alzheimer's disease","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Medical Research Council; Biogen; UK Research and Innovation; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Neurovascular bundle; Cognitive decline; Disease; Cognitive impairment; Cognition; Pathophysiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004170237,0.0004426548,0.0003008474,0.0008407756,0.0002717929,0.0005838447,0.0002189225,0.0003606103,0.0008673597],"category_scores_gemma":[0.001814047,0.0001734245,0.0001503506,0.0006126253,0.000212635,0.000234644,0.0002986541,0.0002995229,0.0001713172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002371149,"about_ca_system_score_gemma":0.0002685796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00288381,"about_ca_topic_score_gemma":0.003264044,"domain_scores_codex":[0.9998667,0.00002465797,0.00001859173,0.00003187577,0.00003638238,0.00002179676],"domain_scores_gemma":[0.9988708,0.0001270891,0.0006152223,0.00003980036,0.000195591,0.0001514307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004485598,0.0000599005,0.9939846,0.0000239793,0.00005894107,0.0001163014,0.00008119507,0.00003540289,0.00173345,0.000007214366,0.00008511353,0.003365364],"study_design_scores_gemma":[0.000005267421,0.0001196949,0.9991203,0.000007350694,0.00002315675,0.000287217,0.00004471786,0.00004796053,0.000224446,0.000037119,0.00008063305,0.000002172675],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986731,0.000815812,0.000068146,0.0000209255,0.00000481566,0.000005096334,0.0001361781,0.000005966161,0.0002701165],"genre_scores_gemma":[0.9992442,0.0002101221,0.0002017639,0.00001939833,0.00001243187,0.000006043876,0.0001723974,0.000001090181,0.0001325228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00288381,"threshold_uncertainty_score":0.005734026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124667173589996,"score_gpt":0.291585551389224,"score_spread":0.280338879653324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}