{"id":"W4416854685","doi":"10.1007/s00467-025-07025-4","title":"Using a multi-institutional pediatric learning health system to characterize induction therapy for incident lupus nephritis in children","year":2025,"lang":"en","type":"article","venue":"Pediatric Nephrology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Patient-Centered Outcomes Research Institute","keywords":"Lupus nephritis; Nephrology; Induction therapy; MEDLINE; Nephritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001314125,0.0002958104,0.0008195052,0.001942461,0.0002970294,0.00003309187,0.0002030421,0.0002932854,0.00001596759],"category_scores_gemma":[0.0003974561,0.0002740501,0.0001519755,0.001660592,0.00004308451,0.0001170081,0.0001271604,0.0005494133,0.00002846137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001234453,"about_ca_system_score_gemma":0.001570837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008628494,"about_ca_topic_score_gemma":0.00004808407,"domain_scores_codex":[0.9968869,0.0003701238,0.00088126,0.000676397,0.0003769936,0.0008083386],"domain_scores_gemma":[0.9987209,0.000231761,0.0002672734,0.0003059226,0.0002296108,0.0002445631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005552925,0.0001908735,0.9934514,0.0007426549,0.000062503,0.0000182576,0.0004487871,0.0001995909,0.0008354435,0.0001662823,0.0005307095,0.002798174],"study_design_scores_gemma":[0.01149952,0.0007918127,0.9742828,0.0001430273,0.0001228873,0.007352567,0.0003290033,0.002875848,0.0000274529,0.00001546945,0.002237283,0.0003222992],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810882,0.003850236,0.008664501,0.001217124,0.001083776,0.003899071,0.00002475084,0.0001509703,0.00002139043],"genre_scores_gemma":[0.9903036,0.001544377,0.00393098,0.001108713,0.002153744,0.0006077379,0.00008693538,0.00004315116,0.0002208001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0191686,"threshold_uncertainty_score":0.9999712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04000227511623093,"score_gpt":0.3379502329161468,"score_spread":0.2979479577999159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}