{"id":"W4416864568","doi":"10.1021/acsnano.5c05949","title":"Local and Systemic Drug Delivery Using Responsive Microneedles","year":2025,"lang":"en","type":"article","venue":"ACS Nano","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Fraser Institute","funders":"National Health and Medical Research Council; Australian Research Council; University of New South Wales; Ramaciotti Foundations","keywords":"Drug delivery; Drug; Targeted drug delivery; Drug administration; Systemic administration; Drug carrier","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003853498,0.0002107453,0.0002518723,0.0001853361,0.0003179506,0.00001714944,0.000215376,0.0002214413,0.00009331303],"category_scores_gemma":[0.0000366594,0.000218149,0.0000489058,0.0002312452,0.0003949552,0.0001502053,0.0001532611,0.0004361813,0.00005413753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612416,"about_ca_system_score_gemma":0.0001535029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005145152,"about_ca_topic_score_gemma":0.00001468137,"domain_scores_codex":[0.9984514,0.000380517,0.0003141724,0.0003391144,0.00009761636,0.0004171644],"domain_scores_gemma":[0.9990173,0.0005094575,0.00007632042,0.0001884969,0.0001060489,0.000102382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001297416,0.0001835497,0.00736689,0.0003684602,0.0004912064,0.0001674298,0.001334012,0.0034947,0.9442247,0.001501716,0.005877579,0.0336924],"study_design_scores_gemma":[0.005370032,0.000086459,0.001074581,0.0005047408,0.0008863848,0.0002582685,0.003755416,0.008632732,0.8438753,0.001368351,0.1333231,0.0008646603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812186,0.01036139,0.005411492,0.000291867,0.001079675,0.0003612893,0.000048879,0.00007497354,0.00115185],"genre_scores_gemma":[0.9932902,0.001194091,0.0004735786,0.002774833,0.00004420712,0.00001743988,0.000008561238,0.00001825989,0.002178774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1274455,"threshold_uncertainty_score":0.8895858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05364781574296752,"score_gpt":0.39750350760957,"score_spread":0.3438556918666025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}