{"id":"W4416867665","doi":"10.1016/j.isci.2025.114301","title":"Context-dependent NMDA receptor dysfunction predicts seizure treatment in mice with human GluN1 variant","year":2025,"lang":"en","type":"article","venue":"iScience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Council on Graduate Studies, Council of Ontario Universities; Schmidt Family Foundation; Simons Foundation Autism Research Initiative","keywords":"NMDA receptor; Epilepsy; Genetically modified mouse; Receptor; Mutant; Extracellular; Synaptic plasticity; Glutamate receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009388797,0.0003994065,0.0002817121,0.0002654881,0.0001556911,0.0003048989,0.0001780955,0.0004393311,0.002036472],"category_scores_gemma":[0.0001557725,0.0001239544,0.0002273733,0.0001417403,0.0003977017,0.0003287203,0.0001760342,0.001055229,0.0003467425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003133069,"about_ca_system_score_gemma":0.0002378162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008752976,"about_ca_topic_score_gemma":0.002925288,"domain_scores_codex":[0.999831,0.00001968556,0.00002659038,0.0000495585,0.00003925997,0.000033997],"domain_scores_gemma":[0.999855,0.00001317156,0.00006501262,0.00001246199,0.000009379442,0.00004494947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004772435,0.00007766351,0.0007044857,0.0000221541,0.00001431021,0.0001604,0.00001646204,0.00008943355,0.9962783,0.0001734811,0.0001050885,0.001881098],"study_design_scores_gemma":[0.0001172703,0.001534196,0.03917456,0.00003128667,0.000133968,0.003234112,0.0001551236,0.002520069,0.9489921,0.0006987588,0.003377609,0.00003091164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946871,0.0005889709,0.001721712,0.0002443361,0.00006305645,0.00002071115,0.001120917,0.0001068515,0.001446373],"genre_scores_gemma":[0.9966538,0.00044489,0.0008379162,0.0001203113,0.000008127203,0.00002840617,0.0004940801,0.00005029971,0.001362118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036472,"threshold_uncertainty_score":0.006812692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0412270000773142,"score_gpt":0.3328932545804871,"score_spread":0.291666254503173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}