{"id":"W4416872743","doi":"10.1681/asn.2025w3z0aab5","title":"Hedgehog Interacting Protein Mediates the Cross-Talk Between Endothelial Cells and Renal Proximal Tubular Cells in a Mouse Model of Renal Ischemia-Reperfusion Injury","year":2025,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Kidney; Hedgehog signaling pathway; Renal injury; Renal stem cell; Kidney tubules; Endothelial stem cell; Proximal tubule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003668498,0.0005918564,0.0005623622,0.0006453103,0.0002807375,0.0003938351,0.0004527509,0.0006525838,0.001979881],"category_scores_gemma":[0.0001111399,0.0004211609,0.0006618015,0.0002603631,0.0004228234,0.0005278929,0.0003037366,0.001628219,0.000421152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003482427,"about_ca_system_score_gemma":0.0003394087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005424912,"about_ca_topic_score_gemma":0.0007541012,"domain_scores_codex":[0.9996455,0.0000478476,0.00003805278,0.0000760844,0.0001034297,0.00008908921],"domain_scores_gemma":[0.9998206,0.000008208153,0.00006642301,0.00001577306,0.00001454491,0.00007443205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000871859,0.0002102632,0.0005318605,0.000117219,0.00002449393,0.0001723065,0.00004207736,0.00009833388,0.9960201,0.0002261048,0.0001273526,0.001558079],"study_design_scores_gemma":[0.0001149811,0.002165864,0.00934482,0.0000272891,0.0001161369,0.0007615993,0.0001050051,0.001777756,0.9823446,0.0001721223,0.00305784,0.00001185568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902659,0.002339283,0.004361,0.0003264754,0.00009179639,0.00008375927,0.0007709333,0.000197539,0.001563185],"genre_scores_gemma":[0.9868765,0.001745508,0.003474658,0.0001559542,0.00003205675,0.000220315,0.0008421987,0.00003455017,0.006618334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001979881,"threshold_uncertainty_score":0.006623387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099477681055723,"score_gpt":0.2718303603173442,"score_spread":0.260835583506787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}