{"id":"W4416872743","doi":"10.1681/asn.2025w3z0aab5","title":"Hedgehog Interacting Protein Mediates the Cross-Talk Between Endothelial Cells and Renal Proximal Tubular Cells in a Mouse Model of Renal Ischemia-Reperfusion Injury","year":2025,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Kidney; Hedgehog signaling pathway; Renal injury; Renal stem cell; Kidney tubules; Endothelial stem cell; Proximal tubule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008346713,0.0001850777,0.0005226017,0.00005182898,0.0001039445,0.00001214963,0.0004806451,0.0001276419,0.000001551954],"category_scores_gemma":[0.0001576954,0.0001188836,0.0003361665,0.0001681277,0.001077103,0.00001057815,0.0004737176,0.0004552647,1.20533e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002945186,"about_ca_system_score_gemma":0.0002249272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006074235,"about_ca_topic_score_gemma":0.000007374492,"domain_scores_codex":[0.9984103,0.0002162134,0.0007004439,0.000215621,0.0002049477,0.0002524479],"domain_scores_gemma":[0.9982107,0.0001487322,0.00111631,0.0002720882,0.0002113747,0.00004078597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004802256,0.00006306793,0.002254082,0.00004511929,0.0002635616,7.578905e-7,0.0007190093,0.001062151,0.9936535,0.000001710434,0.0008222494,0.000634607],"study_design_scores_gemma":[0.0006406733,0.0005142651,0.0004459217,0.00008082555,0.00005771379,0.000006263423,0.0004828481,0.0008950246,0.9959876,0.0000715823,0.0007226111,0.0000946518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977159,0.000268154,0.0006988441,0.0009734672,0.00004867022,0.0002200731,0.00005743977,0.000002505037,0.00001494632],"genre_scores_gemma":[0.9959684,0.0002322064,0.002829065,0.0006131338,0.0002001592,0.000007195788,0.000001286615,0.00001551168,0.0001330145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00233416,"threshold_uncertainty_score":0.4847932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01099477681055723,"score_gpt":0.2718303603173442,"score_spread":0.260835583506787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}