{"id":"W4416876623","doi":"10.1681/asn.20258q224sf0","title":"POINTER: A Phase 2b, Randomized, Placebo-Controlled, Double-Blind Dose-Finding Clinical Study of RMC-035 in Participants at High Risk for Kidney Injury Following Cardiac Surgery","year":2025,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Acute Kidney Injury Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Clinical study; Cardiac surgery; Acute kidney injury; Kidney; Kidney disease; Phase (matter)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002469412,0.002050565,0.002852296,0.0007839959,0.000680932,0.001134282,0.001358301,0.002973334,0.01383533],"category_scores_gemma":[0.00256595,0.0009089992,0.00124983,0.0005927992,0.001333994,0.001427675,0.0006530206,0.003709899,0.001895334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005170531,"about_ca_system_score_gemma":0.002052024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005872278,"about_ca_topic_score_gemma":0.00184074,"domain_scores_codex":[0.9992396,0.0004134557,0.00005465394,0.0001318795,0.00007052177,0.00008989128],"domain_scores_gemma":[0.9988219,0.0003193149,0.0002847778,0.00007728431,0.0001233326,0.0003732853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9526291,0.01773219,0.0007146308,0.001262023,0.0008717633,0.00005657893,0.0000791338,0.0002148036,0.00821436,0.0001848582,0.001571472,0.016469],"study_design_scores_gemma":[0.9468347,0.05141404,0.0007412112,0.000023085,0.0001767758,0.00001952244,0.00001019216,0.0000986365,0.0002157915,0.00005920247,0.0003964222,0.00001047686],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624579,0.004971739,0.002591233,0.001415154,0.0006741188,0.02011195,0.003576426,0.0008009501,0.003400618],"genre_scores_gemma":[0.9391689,0.005404631,0.01064036,0.004410345,0.0009411462,0.02887851,0.003015528,0.0001160981,0.007424447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01383533,"threshold_uncertainty_score":0.04628384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07674184984116511,"score_gpt":0.4412687318820574,"score_spread":0.3645268820408923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}