{"id":"W4416891505","doi":"10.1101/2025.11.27.690823","title":"The subclonal footprint of pervasive early dissemination in pancreatic cancer","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Pancreatic cancer; Genome; Cancer; Gene duplication; Disease; Pancreas; DNA sequencing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526181,0.0001427832,0.0002151481,0.0003971928,0.0001729643,0.0004876732,0.00009960656,0.0002114924,0.001249593],"category_scores_gemma":[0.0003529495,0.0001485141,0.0001078955,0.0004550972,0.0001797126,0.0001659478,0.0003223907,0.0003541827,0.0003371932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001159434,"about_ca_system_score_gemma":0.0001234172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005232323,"about_ca_topic_score_gemma":0.0006478205,"domain_scores_codex":[0.9998426,0.00002258031,0.000007180633,0.00005688038,0.0000424315,0.00002827707],"domain_scores_gemma":[0.9996505,0.00007869305,0.0001019802,0.00005136404,0.00004360328,0.00007384806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006472318,0.00002695375,0.1340278,0.00008249608,0.00003166966,0.0003970847,0.0002439295,0.0002148148,0.8494662,0.0001296272,0.0002604068,0.01447176],"study_design_scores_gemma":[0.00001154025,0.0003107362,0.8649844,0.00001055874,0.00004187309,0.002411766,0.0003287559,0.000999386,0.1276624,0.0003497545,0.002875054,0.00001386076],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972913,0.0006919724,0.001064094,0.00003780683,0.000004685623,0.000004967379,0.0003754531,0.00003888,0.0004909209],"genre_scores_gemma":[0.9978077,0.0002854673,0.0006639226,0.00003903839,0.000007813062,0.00000489123,0.0005882078,0.00001509913,0.000587824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249593,"threshold_uncertainty_score":0.004180253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006949078141307828,"score_gpt":0.2363955607094575,"score_spread":0.2294464825681497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}