{"id":"W4416892702","doi":"10.1182/blood.2025029676","title":"NLRP3 inflammasome blockade treats intestinal inflammation associated with chronic granulomatous disease","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Diet and metabolism studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Institute of Infection and Immunity; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Inflammasome; Chronic granulomatous disease; Inflammation; Inflammatory bowel disease; Colitis; Nicotinamide adenine dinucleotide phosphate; Immune system; Blockade","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130882,0.0004761284,0.000526311,0.0003403336,0.000208453,0.0002777131,0.0002539587,0.0005160971,0.001889038],"category_scores_gemma":[0.0001303742,0.0001187599,0.000437125,0.0002382951,0.0003478939,0.0003520863,0.000323878,0.00175434,0.0003549226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183765,"about_ca_system_score_gemma":0.0003415281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002638222,"about_ca_topic_score_gemma":0.000457976,"domain_scores_codex":[0.9998429,0.00003092126,0.00002148041,0.00002636214,0.00002982226,0.00004858742],"domain_scores_gemma":[0.9998989,0.00001012262,0.00003236011,0.000009443671,0.00001157145,0.00003764396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009155446,0.002398639,0.000542553,0.001129092,0.00008486372,0.0003303923,0.00006133503,0.0002368397,0.9541997,0.0002850311,0.001009633,0.03056649],"study_design_scores_gemma":[0.006167204,0.03947748,0.01399085,0.0002341639,0.0003965267,0.002295936,0.0001486203,0.002291028,0.9096463,0.0004197173,0.02489715,0.00003500168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694091,0.02049042,0.004589895,0.001079216,0.0006534533,0.0003167696,0.0005482217,0.0003736262,0.002539285],"genre_scores_gemma":[0.985463,0.006678706,0.004012198,0.0005691557,0.0001566368,0.0002651342,0.0005241004,0.00003293472,0.002298079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001889038,"threshold_uncertainty_score":0.006319523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00754784793799573,"score_gpt":0.2367927156625917,"score_spread":0.229244867724596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}