{"id":"W4416910510","doi":"10.1093/cid/ciaf632","title":"Cytomegalovirus (CMV)-Specific Cell-Mediated Immunity for Prediction of Postprophylaxis CMV Disease in a Phase 3 Trial of Letermovir Versus Valganciclovir Prophylaxis in Donor CMV-Seropositive/Recipient CMV-Seronegative Kidney Transplant Recipients","year":2025,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Vanderbilt University; Merck","keywords":"Valganciclovir; Cytomegalovirus; Immunity; Kidney transplant; Disease; Cytomegalovirus infections; Clinical trial; Cytomegalovirus infection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004181047,0.001146739,0.001788756,0.0002782752,0.0004031885,0.001162371,0.0006987117,0.001179837,0.001741806],"category_scores_gemma":[0.00225162,0.000531801,0.001567749,0.0002211318,0.0008088856,0.0007666496,0.0003094459,0.002806742,0.0003451788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000671028,"about_ca_system_score_gemma":0.001217096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000561876,"about_ca_topic_score_gemma":0.001374835,"domain_scores_codex":[0.998735,0.0008128764,0.00006722938,0.000175492,0.00009551366,0.0001138938],"domain_scores_gemma":[0.9984183,0.0005190555,0.0003681607,0.0001204821,0.0001095774,0.0004643768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9529283,0.01396845,0.004665026,0.0002687084,0.0006480356,0.00002611259,0.0001353991,0.0004791052,0.004959713,0.00004947895,0.000319573,0.02155203],"study_design_scores_gemma":[0.637353,0.345563,0.01280256,0.00005205814,0.0005565762,0.00006246857,0.00003811965,0.001591729,0.001543612,0.00009176752,0.0003242428,0.00002096846],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968866,0.001343552,0.0001937246,0.0001372316,0.00007983894,0.0008876783,0.0001308846,0.00002702472,0.0003133313],"genre_scores_gemma":[0.9970037,0.0005477684,0.0007544616,0.0002264475,0.00008960773,0.0008310523,0.0001995713,0.00000669952,0.000340663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004181047,"threshold_uncertainty_score":0.02211171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04794573587976842,"score_gpt":0.3724221767467237,"score_spread":0.3244764408669553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}