{"id":"W4416910881","doi":"10.1039/d5ra06597f","title":"Glycogen for Smyd3-antisense oligonucleotide delivery and enhanced liver cancer gene therapy","year":2025,"lang":"en","type":"article","venue":"RSC Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Glycogen; Gene silencing; Nanocarriers; Translation (biology); Liver cancer; Oligonucleotide; Cancer cell; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513295,0.0003365039,0.0001750111,0.0001587564,0.00006920672,0.0001285246,0.0001386422,0.0003209754,0.0008683454],"category_scores_gemma":[0.00008086193,0.00009741016,0.0002041685,0.0001280926,0.0001723349,0.0001993142,0.0002698344,0.0003318729,0.0002621593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000301576,"about_ca_system_score_gemma":0.0002296083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004548101,"about_ca_topic_score_gemma":0.0008666377,"domain_scores_codex":[0.9999511,0.00001015484,0.000003782451,0.00001123336,0.0000142771,0.000009367704],"domain_scores_gemma":[0.9999751,0.000003982246,0.000007784965,0.000002429039,0.000003571031,0.000007122096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003295589,0.00001066613,0.00003356665,0.00008155471,0.000004304451,0.00005333768,0.000009590171,0.0001473255,0.9957629,0.0004973895,0.0001291299,0.003237211],"study_design_scores_gemma":[0.00001681837,0.0002043046,0.0003772704,0.000009354229,0.000009810135,0.0002000599,0.000007965345,0.001342987,0.9901625,0.0001346173,0.007526295,0.000008152464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8381886,0.01814741,0.129409,0.0008413299,0.0004795495,0.0003591207,0.0008759144,0.0007113759,0.01098773],"genre_scores_gemma":[0.9544826,0.006187017,0.03302984,0.0002235136,0.00002850546,0.0001977021,0.0003359025,0.00005658455,0.005458157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008683454,"threshold_uncertainty_score":0.002904892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140273512391884,"score_gpt":0.2836270968187822,"score_spread":0.2722243616948634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}