{"id":"W4416917008","doi":"10.1021/acschemneuro.5c00782","title":"Next-Generation MDMA Analogue SDMA: Pharmacological and Metabolic Insights","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Forensic Toxicology and Drug Analysis","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Stantec (Canada)","funders":"European Regional Development Fund; National Institutes of Health; Universitat de Barcelona; National Institute of Mental Health; Universität des Saarlandes; University of California, San Diego; Universität Wien; Medizinische Universität Wien; Agencia Estatal de Investigación; Austrian Science Fund","keywords":"MDMA; Dopamine; Norepinephrine transporter; Serotonin; Monoamine neurotransmitter; Dopamine transporter; Reuptake; Reuptake inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082646,0.0002584121,0.0002276403,0.000175825,0.00009885506,0.0002589881,0.0002244632,0.0003160865,0.003154774],"category_scores_gemma":[0.00009112499,0.0001140957,0.0002649,0.000128543,0.00009661182,0.0003002168,0.000137194,0.0005753858,0.0007214149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001733017,"about_ca_system_score_gemma":0.0001287074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004960459,"about_ca_topic_score_gemma":0.0008908161,"domain_scores_codex":[0.9999585,0.000005489191,0.000002057002,0.000009534296,0.00001628287,0.000008074355],"domain_scores_gemma":[0.9999732,0.000004697839,0.000006942002,0.000002531472,0.000007607193,0.000005047953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002703083,0.00008886754,0.0004368165,0.0002334367,0.00002559644,0.0003131797,0.00002085042,0.0005543273,0.9702542,0.0005587477,0.001483126,0.02576055],"study_design_scores_gemma":[0.00004714943,0.001229386,0.004356598,0.00002586312,0.00007186536,0.001934769,0.00006302681,0.008712187,0.9466565,0.0004135014,0.03644855,0.00004059212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8834393,0.04129759,0.03917184,0.002471379,0.0003175535,0.000214869,0.004359387,0.0008186813,0.0279094],"genre_scores_gemma":[0.9332665,0.02015052,0.02469996,0.0006593583,0.00007438314,0.0001184852,0.002783743,0.00006948853,0.01817751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003154774,"threshold_uncertainty_score":0.01055378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1206489692241624,"score_gpt":0.4023549187584011,"score_spread":0.2817059495342387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}