{"id":"W4416917008","doi":"10.1021/acschemneuro.5c00782","title":"Next-Generation MDMA Analogue SDMA: Pharmacological and Metabolic Insights","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Forensic Toxicology and Drug Analysis","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Stantec (Canada)","funders":"European Regional Development Fund; National Institutes of Health; Universitat de Barcelona; National Institute of Mental Health; Universität des Saarlandes; University of California, San Diego; Universität Wien; Medizinische Universität Wien; Agencia Estatal de Investigación; Austrian Science Fund","keywords":"MDMA; Dopamine; Norepinephrine transporter; Serotonin; Monoamine neurotransmitter; Dopamine transporter; Reuptake; Reuptake inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003539025,0.0002543347,0.0003600218,0.0001875683,0.0004752069,0.00005919316,0.0004194103,0.0003994924,0.0001816596],"category_scores_gemma":[0.0005828448,0.0002147586,0.00009210389,0.0009634097,0.001295595,0.0002717218,0.000267282,0.0008201929,0.00003809016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002867555,"about_ca_system_score_gemma":0.00008530988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006833383,"about_ca_topic_score_gemma":0.000008048311,"domain_scores_codex":[0.9979221,0.0003395983,0.00036656,0.0007287135,0.0001632172,0.0004797872],"domain_scores_gemma":[0.9989244,0.0004544182,0.00009286215,0.000197206,0.00007238552,0.0002586907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006328602,0.0002125363,0.001812365,0.00000735866,0.00003756828,0.0000290705,0.00006973108,0.00009884089,0.9751765,0.01089927,0.005674346,0.005919203],"study_design_scores_gemma":[0.0009712883,0.00005551243,0.002476673,0.000003790149,0.0003492584,0.00002800376,0.00002457771,0.02232174,0.8925632,0.00112823,0.07981741,0.0002603084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908793,0.001405353,0.0001944467,0.002864765,0.00125796,0.0002039744,0.00001055066,0.00009464808,0.003089028],"genre_scores_gemma":[0.9774323,0.0008241344,0.000109899,0.02051314,0.0001777878,0.00004167618,0.00001541817,0.000007725667,0.0008779474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08261322,"threshold_uncertainty_score":0.87576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1206489692241624,"score_gpt":0.4023549187584011,"score_spread":0.2817059495342387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}