{"id":"W4416918846","doi":"10.1186/s13053-025-00326-7","title":"Skin cancer risk in hereditary mixed cancer syndromes","year":2025,"lang":"en","type":"article","venue":"Hereditary Cancer in Clinical Practice","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Skin cancer; Cancer; Cancer syndrome; Basal cell carcinoma; Li–Fraumeni syndrome; Melanoma; Basal cell; Ovarian cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002115858,0.0003806418,0.0006043297,0.0001503104,0.0000819774,0.00003213236,0.0005762657,0.0006699907,0.0004707267],"category_scores_gemma":[0.002984956,0.0003919272,0.0002439379,0.0005849066,0.0001812614,0.00005930386,0.0003747691,0.001183375,0.00002321753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00027541,"about_ca_system_score_gemma":0.001301506,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01902863,"about_ca_topic_score_gemma":0.04679319,"domain_scores_codex":[0.9955525,0.0009632059,0.001283317,0.001196027,0.0003667838,0.0006381664],"domain_scores_gemma":[0.9974206,0.0009768424,0.0004197467,0.0008082759,0.0002058209,0.0001686835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005270045,0.002782112,0.3425407,0.0004728215,0.001805708,0.001587497,0.0002130401,0.009081515,0.004547989,0.0003025187,0.2644108,0.3669852],"study_design_scores_gemma":[0.008285329,0.0007994743,0.3753248,0.001138833,0.000628065,0.0000742409,0.001719516,0.001669703,0.01388978,0.001728782,0.5931512,0.001590205],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9337456,0.04289716,0.0001313751,0.006688105,0.009690533,0.0007891404,0.0004230795,0.00005757061,0.005577395],"genre_scores_gemma":[0.9432716,0.04352968,0.002041088,0.005468297,0.002346365,0.0009242481,0.00006307782,0.00007869753,0.002276926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.365395,"threshold_uncertainty_score":0.9998533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03068870075451181,"score_gpt":0.3997095939046537,"score_spread":0.3690208931501419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}