{"id":"W4416920317","doi":"10.1021/acsinfecdis.5c00742","title":"Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in <i>Plasmodium falciparum</i> Parasites","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Malaria Research and Control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact","funders":"Faculty of Tropical Medicine, Mahidol University; National Health and Medical Research Council; Mahidol University; University of Melbourne; Deakin University; Monash University; Burnet Institute","keywords":"Peptidomimetic; Drug discovery; Parasite hosting; Drug; Drug development; Plasmodium falciparum; Gene; Nucleotide; Potency","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219583,0.0002710158,0.0001562843,0.0001802188,0.0001002674,0.0001663986,0.000203395,0.0002758471,0.00296983],"category_scores_gemma":[0.0001415255,0.0001304618,0.0001668969,0.0001792476,0.0001310865,0.0001824209,0.0001244643,0.0004632286,0.000464648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002165362,"about_ca_system_score_gemma":0.0001236443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008049775,"about_ca_topic_score_gemma":0.0007434011,"domain_scores_codex":[0.9999305,0.000005667384,0.000003132717,0.00001531365,0.0000272708,0.0000180652],"domain_scores_gemma":[0.9999378,0.00001665485,0.00001717967,0.000004400439,0.00001249771,0.00001149758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001520918,0.00001490011,0.0001183299,0.00004228817,0.000004908787,0.00003833209,0.000009947657,0.0002358042,0.9975101,0.00006458694,0.0001511561,0.00165764],"study_design_scores_gemma":[0.00001454105,0.0001866405,0.005673456,0.000003897832,0.000007733357,0.0001303636,0.00002432909,0.007096876,0.9856488,0.00003957423,0.001165333,0.000008492944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891496,0.000445841,0.005507381,0.000100227,0.00002471459,0.00002271837,0.0009664049,0.0001867699,0.00359619],"genre_scores_gemma":[0.9825062,0.001086942,0.009933682,0.0001064318,0.00001119684,0.00006907817,0.001681446,0.0001119652,0.004493001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00296983,"threshold_uncertainty_score":0.009935081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008835044143246564,"score_gpt":0.2828338386427744,"score_spread":0.2739987944995279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}