{"id":"W4416920832","doi":"10.1016/j.rpth.2025.103280","title":"Comparative safety of drug therapies used in hemophilia A and B in Canada: a multi-center, retrospective study","year":2025,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; St. Joseph’s Healthcare Hamilton; McMaster University; University of British Columbia; Impact","funders":"Canadian Institutes of Health Research; Takeda Canada; BioCryst; Novo Nordisk; Sanofi; Principia Biopharma; Bayer; Pfizer","keywords":"Retrospective cohort study; Drug; Confounding; Novelty; Pharmacoepidemiology; MEDLINE; Adverse effect","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001455531,0.000367258,0.0008162841,0.002664864,0.001673226,0.001251817,0.0009392394,0.0005738353,0.001499155],"category_scores_gemma":[0.004605999,0.0003674871,0.0009676887,0.007726736,0.0008941998,0.0004201503,0.0006463576,0.0007052039,0.0001437384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01843476,"about_ca_system_score_gemma":0.01974983,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9060578,"about_ca_topic_score_gemma":0.8784735,"domain_scores_codex":[0.9964547,0.0002492055,0.0004471919,0.0006365851,0.001787533,0.0004248402],"domain_scores_gemma":[0.9901956,0.0007307174,0.004568082,0.0003191254,0.003212616,0.0009739267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001227701,0.00002181771,0.9969621,0.00008082318,0.0001769374,0.00009155331,0.0001132541,0.00004505309,0.0001029831,0.00003973935,0.0002650947,0.001977806],"study_design_scores_gemma":[0.00001753218,0.0000734832,0.9981792,0.00004655046,0.0001527209,0.0003081153,0.0002391527,0.0001239331,0.00006386213,0.00001228821,0.0007723311,0.00001083411],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880583,0.004570074,0.0002380735,0.0001569686,0.00001248537,0.0001140743,0.005013107,0.00001258516,0.001824356],"genre_scores_gemma":[0.9950944,0.001752804,0.0002388596,0.0001612212,0.00001294406,0.00004192811,0.002502496,0.00000597151,0.0001892976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09394217,"threshold_uncertainty_score":0.1889908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1785767377934988,"score_gpt":0.4637301775376856,"score_spread":0.2851534397441868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}