{"id":"W4416930849","doi":"10.1055/s-0045-1812988","title":"Safety and Efficacy in Pediatric Patients with Relapsed/Refractory Classic Hodgkin Lymphoma enrolled on an Intergroup Randomized Phase II Study of the Combinations of Ipilimumab, Nivolumab and Brentuximab Vedotin (E4412)","year":2025,"lang":"","type":"article","venue":"Klinische Pädiatrie","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Brentuximab vedotin; Hodgkin lymphoma; Nivolumab; Lymphoma; Phases of clinical research; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001098804,0.0007012485,0.001727738,0.0002318721,0.0003058206,0.0007959616,0.0004910668,0.0008297288,0.001564229],"category_scores_gemma":[0.001224582,0.0004087388,0.00117323,0.0003497055,0.0008589493,0.0008273,0.0003176017,0.002201996,0.0003163838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007768221,"about_ca_system_score_gemma":0.000969909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006015446,"about_ca_topic_score_gemma":0.0012918,"domain_scores_codex":[0.9993964,0.0003147079,0.00003167494,0.00009908381,0.00005670322,0.0001013125],"domain_scores_gemma":[0.9991308,0.0002157169,0.0002524176,0.00007698243,0.0000366792,0.0002874656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8178695,0.01573543,0.06105154,0.0004516232,0.002506336,0.0004712031,0.0002436964,0.001729618,0.01159878,0.0002465551,0.001949092,0.08614662],"study_design_scores_gemma":[0.4478633,0.4138593,0.1252112,0.0000907832,0.002209083,0.001059331,0.0002342443,0.001962062,0.003813091,0.0003571469,0.003289995,0.000050533],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997537,0.001356407,0.0001168053,0.0001217891,0.00003063791,0.0001560418,0.0002736541,0.00001442205,0.0003932354],"genre_scores_gemma":[0.997116,0.0008639953,0.0003124374,0.0003188811,0.00008066239,0.0002584191,0.0007246265,0.000007755299,0.0003171923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001727738,"threshold_uncertainty_score":0.005811036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006988153577421633,"score_gpt":0.2628725201907544,"score_spread":0.2558843666133328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}