{"id":"W4416934403","doi":"10.3389/fonc.2025.1659304","title":"Unraveling the synergy of radiotherapy and immune checkpoint inhibitors in NSCLC: emerging clinical evidence and novel therapeutic strategies","year":2025,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Health Canada; Pfizer Canada; Pfizer","keywords":"Abscopal effect; Radiation therapy; Clinical trial; Chemotherapy; Immunotherapy; Immune system; Lung cancer; Immune checkpoint","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003086657,0.0006549984,0.002119418,0.0008238408,0.0002083816,0.00206104,0.0009492985,0.001221776,0.00545599],"category_scores_gemma":[0.004324836,0.0002851993,0.002151928,0.000796925,0.000486232,0.002349545,0.000957526,0.002269751,0.0008295366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006541737,"about_ca_system_score_gemma":0.002394101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007347546,"about_ca_topic_score_gemma":0.002343343,"domain_scores_codex":[0.9992357,0.0003436993,0.0001183457,0.00009995863,0.0001317437,0.0000703984],"domain_scores_gemma":[0.9976797,0.001600506,0.0002722162,0.00005402101,0.0003075069,0.00008600895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001849831,0.0002884375,0.001888163,0.0457766,0.001413075,0.000232476,0.0001599296,0.002117868,0.002621486,0.008719367,0.01117483,0.9237579],"study_design_scores_gemma":[0.002817068,0.007012287,0.01015389,0.0908619,0.01088828,0.001558208,0.0007817416,0.006944952,0.003172865,0.04378048,0.8218576,0.0001707265],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002313231,0.9914405,0.0007601735,0.003612393,0.0002509613,0.00005153826,0.0001088691,0.00002035094,0.00144194],"genre_scores_gemma":[0.03171922,0.9610665,0.002059805,0.003342472,0.0007927928,0.0001481531,0.0002781569,0.00001432697,0.0005784536],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00545599,"threshold_uncertainty_score":0.01825213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.063233346140609,"score_gpt":0.4164298494710535,"score_spread":0.3531965033304445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}