{"id":"W4416935989","doi":"10.3389/fnagi.2025.1736855","title":"Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions","year":2025,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Neurobiology of Language and Bilingualism","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"","keywords":"Primary progressive aphasia; Neurocognitive; Identification (biology); Aphasia; Biomarker; Diagnostic test","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0825153,0.001446928,0.004369089,0.00631172,0.003068061,0.006764258,0.007058099,0.007369177,0.002870017],"category_scores_gemma":[0.1118258,0.0008958721,0.001483569,0.00238443,0.01066929,0.01853221,0.006769681,0.0125614,0.001893037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005626142,"about_ca_system_score_gemma":0.0157083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01189471,"about_ca_topic_score_gemma":0.02047848,"domain_scores_codex":[0.9774504,0.009582545,0.0051216,0.003073939,0.003824452,0.000947169],"domain_scores_gemma":[0.8094606,0.124479,0.006778067,0.003782568,0.04875642,0.006743253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002047998,0.0001436861,0.01154478,0.00709427,0.0001509185,0.0008521616,0.002496151,0.0005985197,0.0005980727,0.01710824,0.0647804,0.894428],"study_design_scores_gemma":[0.0001745329,0.0006306312,0.02829229,0.09647029,0.0008023661,0.01558094,0.0387893,0.004543005,0.0008676673,0.2704375,0.5427185,0.0006930477],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004018854,0.6325456,0.008689115,0.342445,0.00819073,0.00009729996,0.0001730726,0.0002067813,0.003633508],"genre_scores_gemma":[0.06774087,0.7624292,0.04434265,0.08495234,0.03818673,0.0004327057,0.000738602,0.0001627907,0.00101419],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0825153,"threshold_uncertainty_score":0.4363878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03446684269662334,"score_gpt":0.2970906634789898,"score_spread":0.2626238207823665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}