{"id":"W4416938281","doi":"10.1016/j.phymed.2025.157659","title":"Radix Aucklandiae inhibits M1 macrophage polarization to alleviate ulcerative colitis by modulating gut microbial production of indole-3-aldehyde","year":2025,"lang":"en","type":"article","venue":"Phytomedicine","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Science and Technology Planning Project of Guangdong Province; Medical Science and Technology Foundation of Guangdong Province; Traditional Chinese Medicine Bureau of Guangdong Province; National Natural Science Foundation of China","keywords":"Ulcerative colitis; Macrophage; Radix (gastropod); Colitis; Macrophage polarization; Downregulation and upregulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009796207,0.0004749265,0.0003654146,0.0003662005,0.0002400354,0.0002629581,0.0002023811,0.0002899487,0.002034153],"category_scores_gemma":[0.00009699833,0.0001018045,0.000265186,0.0002063896,0.000215823,0.0001712468,0.0001648144,0.00098016,0.0002864715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001594605,"about_ca_system_score_gemma":0.0003055985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001127065,"about_ca_topic_score_gemma":0.0023105,"domain_scores_codex":[0.9999101,0.00001792988,0.000007550491,0.0000132203,0.00001602734,0.00003521622],"domain_scores_gemma":[0.9999396,0.000006377225,0.00001744002,0.000006607037,0.00000732542,0.00002280559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002731482,0.0005283754,0.0001690615,0.0001211766,0.00001575318,0.00008694485,0.00002521892,0.00008216401,0.9887338,0.0000746818,0.0001531242,0.007278353],"study_design_scores_gemma":[0.000574607,0.008703312,0.01181401,0.0000509886,0.00009129185,0.0003698466,0.0001137799,0.0008383825,0.9706993,0.0001153373,0.006610985,0.00001801577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939063,0.002302861,0.0007676199,0.0001938605,0.00007472913,0.00005817685,0.0001765928,0.000124597,0.002395245],"genre_scores_gemma":[0.9944431,0.001077099,0.0009421138,0.000114813,0.00002105239,0.00003626158,0.0002060093,0.00001472974,0.003144782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002034153,"threshold_uncertainty_score":0.006804943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005549397074059915,"score_gpt":0.2492869659730549,"score_spread":0.2437375688989949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}