{"id":"W4416943253","doi":"10.1080/15384047.2025.2590881","title":"Toll-like receptor 4 inhibition sensitizes non-small cell lung cancer to radiotherapy","year":2025,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Canada Excellence Research Chairs, Government of Canada; Université de Sherbrooke; Cancer Research Society","keywords":"Radiation therapy; Lung cancer; Receptor; Sensitivity (control systems); Cell; Cell growth; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002597177,0.0003021687,0.0004390255,0.000274552,0.0002617367,0.00001967158,0.0002023691,0.0005019995,0.001425292],"category_scores_gemma":[0.000009074241,0.0002612083,0.0001411251,0.0003153363,0.0001552929,0.00006933527,0.00004271539,0.0002837505,0.0001307846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524162,"about_ca_system_score_gemma":0.000325785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005534562,"about_ca_topic_score_gemma":0.00008727171,"domain_scores_codex":[0.9982674,0.0003468715,0.0003784758,0.000482048,0.00002182183,0.000503403],"domain_scores_gemma":[0.9992148,0.0001227746,0.0001329224,0.0003581357,0.0001429339,0.00002845835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001469864,0.00004954522,0.00332675,0.00001971164,0.0003394272,0.000001138387,0.0009634197,0.00003114966,0.9113268,0.0001301292,0.03788662,0.04445549],"study_design_scores_gemma":[0.002129073,0.0001701709,0.002257258,0.0000866604,0.00002305625,0.000002521821,0.00008727892,0.000009193077,0.6439393,0.00003220172,0.3510385,0.0002248463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9317851,0.05690518,0.001717065,0.004331249,0.003724329,0.0008249563,0.00005546282,0.0001143534,0.0005422847],"genre_scores_gemma":[0.9162294,0.04620205,0.0003218492,0.0160914,0.0003839041,0.001087999,0.0003351034,0.00005860361,0.01928966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3131519,"threshold_uncertainty_score":0.999984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008463146016488123,"score_gpt":0.2740885293947213,"score_spread":0.2656253833782332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}