{"id":"W4416946456","doi":"10.1038/s41380-025-03365-7","title":"Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium","year":2025,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; McGill University; Université de Montréal; Montreal Neurological Institute and Hospital; Institut national de psychiatrie légale Philippe-Pinel","funders":"National Institutes of Health","keywords":"Impulsivity; Aggression; White matter; Grey matter; Schizophrenia (object-oriented programming); Inferior parietal lobule; Psychosis; Internal capsule; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001946955,0.000927153,0.001340205,0.003013395,0.00112466,0.001099598,0.001213545,0.0007602355,0.002927148],"category_scores_gemma":[0.00443602,0.0007681985,0.001344547,0.003933534,0.0006245887,0.0004776592,0.002435531,0.0005842892,0.0006123468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005516654,"about_ca_system_score_gemma":0.0007062434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01649284,"about_ca_topic_score_gemma":0.02018623,"domain_scores_codex":[0.9981897,0.0004897453,0.0002026745,0.0006560968,0.0002716967,0.0001900425],"domain_scores_gemma":[0.9975901,0.0005469867,0.0007304637,0.0005231535,0.0003017297,0.0003076626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002634815,0.00007471068,0.9721158,0.0001818227,0.005396097,0.001043728,0.0006052867,0.0006543387,0.005317616,0.0001957834,0.003048044,0.008732007],"study_design_scores_gemma":[0.0001055012,0.00007251569,0.9949727,0.00003497248,0.001273023,0.00110264,0.0002549742,0.0002885412,0.0003512565,0.0001172514,0.001407419,0.00001914286],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875574,0.0006235575,0.000467706,0.00006217502,0.000007558166,0.00001908437,0.01093853,0.00002715412,0.0002967539],"genre_scores_gemma":[0.9703792,0.0004917768,0.0008704683,0.00005262132,0.00001515606,0.00006266971,0.02773792,0.0000843104,0.0003058022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01649284,"threshold_uncertainty_score":0.0327937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617746001840387,"score_gpt":0.3190584933859354,"score_spread":0.3028810333675316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}