{"id":"W4416949610","doi":"10.1111/acel.70315","title":"Genetic Reduction of the Translational Repressors <scp>FMRP</scp> and <scp>4E</scp> ‐ <scp>BP2</scp> Preserves Memory in Mouse Models of Alzheimer's Disease","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Queen's University; McGill University; Centre for Research on Brain Language and Music; Carleton University","funders":"Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional; International Brain Research Organization; International Union of Biochemistry and Molecular Biology; Instituto Serrapilheira; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Company of Biologists; Alzheimer's Society; American Society for Biochemistry and Molecular Biology; International Society for Neurochemistry; Alzheimer's Association","keywords":"Translation (biology); Messenger RNA; Hippocampal formation; Ribonucleoprotein; Transgene; Repressor; Genetically modified mouse; Protein biosynthesis; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735927,0.0002429044,0.0002285957,0.0001242996,0.00009614322,0.00002345618,0.000323548,0.0001334998,0.000001144753],"category_scores_gemma":[0.0001411633,0.0002306051,0.0001356304,0.0002260787,0.0002133679,0.00001449003,0.0002283222,0.0001424763,6.619165e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007308605,"about_ca_system_score_gemma":0.0001597452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000824655,"about_ca_topic_score_gemma":0.00002726111,"domain_scores_codex":[0.9982964,0.0001349206,0.0004561874,0.0005591727,0.0002452207,0.0003080353],"domain_scores_gemma":[0.9990301,0.00008802411,0.0001927219,0.0005050465,0.00008694878,0.00009715738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009103648,0.0003045549,0.02924981,0.0002628683,0.000140565,0.000002385596,0.001409182,0.04370289,0.9216217,0.00005328511,0.002690647,0.0005529594],"study_design_scores_gemma":[0.0009056939,0.00004860949,0.2012723,0.00006454796,0.000114848,0.000002503885,0.0007076261,0.002385215,0.792147,0.001258139,0.001045024,0.00004844116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852245,0.01112526,0.0001963479,0.0000668472,0.0001526088,0.0004336517,0.00004755818,0.00001103819,0.002742225],"genre_scores_gemma":[0.9953292,0.001430807,0.0005176237,0.00008550262,0.00002065716,0.00003244527,0.00005114055,0.00003270808,0.002499918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1720225,"threshold_uncertainty_score":0.9403801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107894856581463,"score_gpt":0.222943728968508,"score_spread":0.2121542433103617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}