{"id":"W4416949610","doi":"10.1111/acel.70315","title":"Genetic Reduction of the Translational Repressors <scp>FMRP</scp> and <scp>4E</scp> ‐ <scp>BP2</scp> Preserves Memory in Mouse Models of Alzheimer's Disease","year":2025,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Queen's University; McGill University; Centre for Research on Brain Language and Music; Carleton University","funders":"Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional; International Brain Research Organization; International Union of Biochemistry and Molecular Biology; Instituto Serrapilheira; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Company of Biologists; Alzheimer's Society; American Society for Biochemistry and Molecular Biology; International Society for Neurochemistry; Alzheimer's Association","keywords":"Translation (biology); Messenger RNA; Hippocampal formation; Ribonucleoprotein; Transgene; Repressor; Genetically modified mouse; Protein biosynthesis; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001130767,0.0007068117,0.0003234602,0.0004888547,0.0002153566,0.0003121545,0.0003019258,0.0003937011,0.001433504],"category_scores_gemma":[0.00009978196,0.0001772727,0.0002407303,0.0002173271,0.0004422195,0.0001959224,0.0002013166,0.0007623683,0.0004016617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003474089,"about_ca_system_score_gemma":0.0002643823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001279615,"about_ca_topic_score_gemma":0.001858342,"domain_scores_codex":[0.9998531,0.00001538327,0.00001572503,0.00004032596,0.00004425035,0.00003113309],"domain_scores_gemma":[0.9998499,0.00001491841,0.0000665229,0.0000150361,0.00001168967,0.00004188171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009131501,0.00002240508,0.00003734442,0.00001512334,0.00000444978,0.00002440915,0.000005190926,0.00003124457,0.9991934,0.00007234636,0.00001959719,0.0004831939],"study_design_scores_gemma":[0.00001586207,0.0001844753,0.001531545,0.000004564205,0.00001731058,0.0001368968,0.00001220352,0.0003586492,0.9960728,0.0000479774,0.001612422,0.000005335588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933168,0.00113508,0.00306569,0.0001462379,0.00005014913,0.00003122758,0.0006677502,0.0003101538,0.001276882],"genre_scores_gemma":[0.9883971,0.001077829,0.00385738,0.00006195466,0.00002336525,0.00005699155,0.0008172157,0.000129419,0.00557872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433504,"threshold_uncertainty_score":0.004795492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107894856581463,"score_gpt":0.222943728968508,"score_spread":0.2121542433103617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}