{"id":"W4416955423","doi":"10.1039/d5ra07017a","title":"Design, synthesis, and characterization of novel 5-ethylsulfonyl-indazole-3-carboxamides as dual VEGFR-2 and EGFR inhibitors: apoptotic antiproliferative and immunomodulatory evaluations","year":2025,"lang":"en","type":"article","venue":"RSC Advances","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Inimex Pharmaceuticals (Canada)","funders":"Princess Nourah Bint Abdulrahman University; Karlsruhe Institute of Technology","keywords":"Docking (animal); Enzyme; EGFR inhibitors; Apoptosis; Isatin; Cell culture; Molecular dynamics; Hydrogen bond","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163907,0.0003887428,0.0003320704,0.0002155327,0.00009506236,0.0001890897,0.0004451976,0.0002180563,0.0008886069],"category_scores_gemma":[0.0001164259,0.0001422882,0.000214729,0.0001625965,0.0001179746,0.0001719204,0.0001344753,0.0002684365,0.0003520635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002619792,"about_ca_system_score_gemma":0.0002675501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004761254,"about_ca_topic_score_gemma":0.001583441,"domain_scores_codex":[0.9999366,0.000007008133,0.000005905752,0.0000128324,0.00002074195,0.00001688313],"domain_scores_gemma":[0.9999542,0.00000290108,0.00001543184,0.000003340467,0.0000123819,0.00001178494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003402249,0.0003169745,0.0002530155,0.0003036826,0.00002731335,0.0002544111,0.0000386197,0.002452627,0.9727362,0.0004796601,0.0003063874,0.02249077],"study_design_scores_gemma":[0.0006559024,0.008771245,0.004582285,0.00005354491,0.0001434059,0.0008571843,0.00004198153,0.008230877,0.9530251,0.0002010445,0.02338502,0.00005251942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738436,0.007209993,0.01234754,0.0001568935,0.00005377407,0.0006252234,0.0007218252,0.0001576134,0.004883562],"genre_scores_gemma":[0.9788129,0.004193936,0.01248829,0.00008935936,0.00002018336,0.0002923873,0.0006299484,0.00001453802,0.003458339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008886069,"threshold_uncertainty_score":0.002972722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01361105154566557,"score_gpt":0.2872287446521037,"score_spread":0.2736176931064381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}