{"id":"W4416965554","doi":"10.1126/scitranslmed.aec0500","title":"Locking down IgE","year":2025,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Antibody; Immunoglobulin E; Receptor; Immune system; Immunoglobulin Fc Fragments; Fc receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005535458,0.0001132182,0.0001817922,0.0003406088,0.000461278,0.000007075261,0.0003821504,0.00007952808,0.001569073],"category_scores_gemma":[0.00008297656,0.00008353969,0.0000337322,0.0007952399,0.002467885,0.0001242733,0.00002908804,0.0002215007,0.0002507387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000243979,"about_ca_system_score_gemma":0.0002554449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008178472,"about_ca_topic_score_gemma":0.00001967824,"domain_scores_codex":[0.998967,0.00004309459,0.0002526093,0.0003160549,0.00008479458,0.0003364488],"domain_scores_gemma":[0.9994588,0.0001729978,0.00004320166,0.0001930566,0.0001131672,0.00001877499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003008597,0.0000308712,0.001794488,0.000006477127,0.00001972197,0.000001344119,0.000311334,0.000008626033,0.9500169,0.03664934,0.001105519,0.01002525],"study_design_scores_gemma":[0.00508303,0.0002674753,0.03694078,0.0002862343,0.00009579051,0.00008353161,0.0006671977,0.00008623393,0.6581162,0.02478541,0.273226,0.0003621618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7144252,0.01803776,0.009143758,0.05259401,0.008649235,0.000560232,0.00001720223,0.0002873603,0.1962852],"genre_scores_gemma":[0.9932263,0.00003486716,0.0001137728,0.0007776829,0.00004099731,0.000007127192,0.00002669383,0.000003152505,0.00576943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2919008,"threshold_uncertainty_score":0.9993436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513345376426082,"score_gpt":0.2751612922616895,"score_spread":0.2600278384974287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}