{"id":"W4416967325","doi":"10.1001/jamapsychiatry.2025.3636","title":"Muscarinic Receptor Activators—What Is Their Place in Clinical Care?","year":2025,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Muscarinic acetylcholine receptor; Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M3; Muscarinic acetylcholine receptor M2; Receptor; Muscarinic acetylcholine receptor M5","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007645769,0.000658889,0.002070325,0.001161249,0.001483532,0.004926667,0.002239688,0.006812908,0.006098394],"category_scores_gemma":[0.01110407,0.0004453398,0.000964186,0.0007429098,0.004601866,0.008591673,0.00163122,0.01160606,0.002650085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00275359,"about_ca_system_score_gemma":0.007481771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003491367,"about_ca_topic_score_gemma":0.01027803,"domain_scores_codex":[0.9978175,0.0009543389,0.0002222109,0.0002298032,0.0004785496,0.0002976433],"domain_scores_gemma":[0.9909689,0.004697648,0.0006147237,0.0004152958,0.002237675,0.001065706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007247019,0.0003568125,0.001976483,0.002607616,0.0001149486,0.001465537,0.0004258016,0.0004706647,0.001488447,0.1389797,0.2480226,0.6033666],"study_design_scores_gemma":[0.0006420401,0.001099125,0.002098578,0.008632079,0.0001896897,0.002156977,0.00176563,0.000667695,0.0006003216,0.07887799,0.9031421,0.0001277428],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0009937572,0.4608845,0.001572948,0.5080587,0.01620885,0.00001705347,0.00005357006,0.00007509436,0.01213562],"genre_scores_gemma":[0.03023002,0.6635602,0.005136135,0.2038498,0.09067995,0.0001026112,0.00009811309,0.00008979542,0.006253314],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007645769,"threshold_uncertainty_score":0.04043519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008242864126542139,"score_gpt":0.2908631171929872,"score_spread":0.2826202530664451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}