{"id":"W4416967325","doi":"10.1001/jamapsychiatry.2025.3636","title":"Muscarinic Receptor Activators—What Is Their Place in Clinical Care?","year":2025,"lang":"en","type":"article","venue":"JAMA Psychiatry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Muscarinic acetylcholine receptor; Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M3; Muscarinic acetylcholine receptor M2; Receptor; Muscarinic acetylcholine receptor M5","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003781019,0.0002033385,0.000244011,0.00007765735,0.00007162779,0.0000954623,0.0003142064,0.0004911065,0.0001935875],"category_scores_gemma":[0.00004664516,0.0001840581,0.0002416808,0.0001885119,0.00004274418,0.00001483858,0.000138998,0.0003267961,0.00002555288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000261366,"about_ca_system_score_gemma":0.0002850584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001963669,"about_ca_topic_score_gemma":0.00005626755,"domain_scores_codex":[0.9984673,0.000142052,0.0004472992,0.0005575746,0.0001012322,0.000284512],"domain_scores_gemma":[0.9992239,0.00003142711,0.0001009057,0.0005074586,0.00005739284,0.00007884447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002018881,0.0009444951,0.1931615,0.000355675,0.0005872331,0.000003438405,0.001577893,0.00006339129,0.2541158,0.004941978,0.1521186,0.3901111],"study_design_scores_gemma":[0.005370638,0.0006064121,0.0111843,0.000567987,0.00004100924,0.000004063695,0.01156939,0.00007020788,0.2572506,0.0021189,0.7104049,0.0008115601],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830828,0.007103791,0.0003339545,0.002058256,0.004848416,0.0002169807,0.00001421555,0.00002001923,0.002321591],"genre_scores_gemma":[0.9885406,0.00227757,0.001997051,0.005109788,0.0009326565,0.00003129258,0.00007643922,0.00003132492,0.001003272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5582864,"threshold_uncertainty_score":0.7505672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008242864126542139,"score_gpt":0.2908631171929872,"score_spread":0.2826202530664451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}