{"id":"W4416973633","doi":"10.1016/j.fertnstert.2025.07.955","title":"WHOLE GENOME AND TRANSCRIPTOME SEQUENCING OF EMBRYOS IDENTIFIES POTENTIAL CAUSE OF RECURRENT PREGNANCY LOSS: A CLINICAL CASE STUDY","year":2025,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Genomics","funders":"","keywords":"Transcriptome; Genome; Whole genome sequencing; Embryo; Pregnancy; Reference genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003615089,0.0005410242,0.0004557888,0.0008709875,0.0007491295,0.0007680832,0.000640777,0.001863784,0.002049947],"category_scores_gemma":[0.002382755,0.0003194328,0.000563181,0.0003478309,0.0006146521,0.0003220448,0.0007336351,0.001024282,0.0005354515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003997202,"about_ca_system_score_gemma":0.0003112986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008457937,"about_ca_topic_score_gemma":0.001015633,"domain_scores_codex":[0.9995678,0.00005311692,0.00003539835,0.0001253492,0.0001258919,0.00009242611],"domain_scores_gemma":[0.9993976,0.000256887,0.0001043286,0.00005230506,0.00008231284,0.0001064976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001562991,0.00006021604,0.0462207,0.00007735204,0.00003823897,0.9179847,0.0006598341,0.0003251792,0.01961428,0.0007089715,0.001113932,0.01304034],"study_design_scores_gemma":[0.00001108111,0.0001079647,0.0272562,0.00004098524,0.00006307836,0.9609703,0.0004419186,0.00108469,0.006534039,0.0005908964,0.002881567,0.00001713388],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875178,0.001802897,0.004424352,0.001530332,0.00009064996,0.00009294119,0.0005043268,0.00007460674,0.003962192],"genre_scores_gemma":[0.9933334,0.0009750833,0.003309531,0.0003385351,0.00007898483,0.00002561896,0.0002698393,0.0000414165,0.001627773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002049947,"threshold_uncertainty_score":0.006857753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0632441178001907,"score_gpt":0.3550969343441913,"score_spread":0.2918528165440006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}