{"id":"W4416973962","doi":"10.1016/j.fertnstert.2025.07.246","title":"WHOLE GENOME AND TRANSCRIPTOME SEQUENCING IDENTIFIES VARIANTS ASSOCIATED WITH REDUCED EMBRYO VIABILITY, PROVIDING AN OPPORTUNITY TO IMPROVE EMBRYO SELECTION AND CLINICAL OUTCOMES","year":2025,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"Ovarian function and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Genome Canada","keywords":"Transcriptome; Selection (genetic algorithm); Infertility; Fertility; Embryo; Genome; Whole genome sequencing; Human genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001032824,0.0005346416,0.0006327303,0.0008712465,0.0003588428,0.001091136,0.0004578526,0.0009689577,0.003874448],"category_scores_gemma":[0.003104334,0.0001630995,0.0006820692,0.0007276297,0.0003250913,0.0003084739,0.0005775829,0.0009114566,0.0005208284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002276777,"about_ca_system_score_gemma":0.0004529273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001656237,"about_ca_topic_score_gemma":0.00269459,"domain_scores_codex":[0.9995195,0.0001086294,0.00004258848,0.0001508584,0.0001244237,0.00005407915],"domain_scores_gemma":[0.9989673,0.0006125523,0.0001803308,0.00006548737,0.0001044209,0.00006994689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002975353,0.0002954527,0.5095289,0.001264574,0.002400364,0.007608566,0.0007252006,0.003597578,0.2032206,0.00620885,0.02175505,0.2404195],"study_design_scores_gemma":[0.0004691584,0.0007785065,0.8439753,0.0008255405,0.002324119,0.01335997,0.0008043155,0.008113598,0.04520402,0.01994736,0.0640076,0.000190596],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9285486,0.01557444,0.02077928,0.005156128,0.0007938751,0.000104345,0.01978698,0.0004515985,0.008804786],"genre_scores_gemma":[0.9633843,0.004905236,0.0165358,0.001976883,0.0003697374,0.00008050074,0.009602302,0.0002718237,0.002873526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003874448,"threshold_uncertainty_score":0.01296133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04647127703474264,"score_gpt":0.3206006696807226,"score_spread":0.27412939264598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}