{"id":"W4416976611","doi":"10.1038/s41541-025-01326-3","title":"Polyvalent mRNA vaccine targeting outer surface protein C affords multi-strain protection against Lyme disease","year":2025,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Public Health Agency of Canada; University of Saskatchewan; University of Ottawa; Health Canada","funders":"National Institute of Allergy and Infectious Diseases; Health Canada; National Institutes of Health; Government of Canada","keywords":"Lyme disease; Antibody; Messenger RNA; Antibody response; Antigen; Epitope; Polyvalent Vaccine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002610529,0.0004259894,0.0004060853,0.0002154318,0.000409674,0.00005331423,0.0002901343,0.0002537039,0.0004958319],"category_scores_gemma":[0.0007139912,0.0003808179,0.0002265012,0.0003826483,0.00004026018,0.0001609341,0.0001717539,0.0003616548,0.0003251787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001494717,"about_ca_system_score_gemma":0.0001914497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002107706,"about_ca_topic_score_gemma":0.0001530826,"domain_scores_codex":[0.9978392,0.0002995095,0.0005260215,0.000655216,0.00006157241,0.00061844],"domain_scores_gemma":[0.9989281,0.00005718029,0.0001983325,0.0004948745,0.0002377238,0.00008373048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008574956,0.001044941,0.09615472,0.0003443736,0.0005396281,0.00003106534,0.0001213834,0.000406879,0.8787802,0.0002719295,0.0123236,0.009123826],"study_design_scores_gemma":[0.01530693,0.0006682235,0.4175429,0.0009684801,0.0006181233,0.00002492699,0.000523429,0.000900354,0.4822753,0.0006471823,0.07847773,0.002046326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871457,0.005350709,0.001150298,0.001443461,0.001745718,0.001908239,0.0001894093,0.0006524012,0.0004140639],"genre_scores_gemma":[0.9903257,0.00005166118,0.0001885107,0.0003610257,0.0001648994,0.0002843918,0.0002254474,0.0000471947,0.008351164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3965048,"threshold_uncertainty_score":0.9998644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239637976281403,"score_gpt":0.2503405998320362,"score_spread":0.2379442200692222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}