{"id":"W4416976611","doi":"10.1038/s41541-025-01326-3","title":"Polyvalent mRNA vaccine targeting outer surface protein C affords multi-strain protection against Lyme disease","year":2025,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Public Health Agency of Canada; University of Saskatchewan; University of Ottawa; Health Canada","funders":"National Institute of Allergy and Infectious Diseases; Health Canada; National Institutes of Health; Government of Canada","keywords":"Lyme disease; Antibody; Messenger RNA; Antibody response; Antigen; Epitope; Polyvalent Vaccine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001218523,0.0004033998,0.000285466,0.0002604855,0.0001041014,0.0002391921,0.0001857485,0.000314313,0.0009684575],"category_scores_gemma":[0.000132569,0.00009964532,0.000168794,0.0001136348,0.0002283248,0.0002548698,0.0001753569,0.000647006,0.0002179574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002318513,"about_ca_system_score_gemma":0.000269473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004740989,"about_ca_topic_score_gemma":0.0007543133,"domain_scores_codex":[0.9998465,0.00001763847,0.00001274835,0.00003245859,0.00004268892,0.00004798824],"domain_scores_gemma":[0.9999202,0.00001251263,0.00002245275,0.00000854027,0.00001383999,0.00002240176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002705994,0.0002639654,0.0001986798,0.000065598,0.000008834136,0.00003600416,0.00001532769,0.0003402369,0.9899838,0.000138565,0.000146943,0.008531337],"study_design_scores_gemma":[0.0001364439,0.008820533,0.004827091,0.00002521363,0.00008513585,0.0003347593,0.00003888232,0.003115553,0.978285,0.0001129182,0.004207111,0.00001140904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925261,0.0009882821,0.004285386,0.0001216813,0.00009197187,0.00005374139,0.0001148473,0.0001006573,0.001717349],"genre_scores_gemma":[0.9933675,0.0008258533,0.0033816,0.00009359299,0.00003481671,0.00003833741,0.0003077354,0.00001889388,0.001931602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009684575,"threshold_uncertainty_score":0.00323981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239637976281403,"score_gpt":0.2503405998320362,"score_spread":0.2379442200692222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}