{"id":"W4416978059","doi":"10.1002/mas.70016","title":"Recent Advances in On‐Tissue Chemical Derivatization Strategies for Enhancing MALDI‐MSI","year":2025,"lang":"en","type":"article","venue":"Mass Spectrometry Reviews","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Derivatization; Reagent; Mass spectrometry; Detection limit; Atmospheric-pressure chemical ionization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003606802,0.0003138404,0.000628476,0.00031616,0.0001008878,0.00009483642,0.0003998456,0.0001631509,0.003338206],"category_scores_gemma":[0.0002997745,0.0002953338,0.0001297424,0.001541388,0.00004500284,0.0001923743,0.00005056745,0.0003107402,0.00002276415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003959801,"about_ca_system_score_gemma":0.00007378897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003166257,"about_ca_topic_score_gemma":0.00003176563,"domain_scores_codex":[0.9979548,0.00002926348,0.0007947103,0.0006029377,0.0001722436,0.0004460876],"domain_scores_gemma":[0.9988567,0.0001764986,0.0002392587,0.0006038515,0.00005969131,0.00006399768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003443978,0.0001955789,0.0003305101,0.001138039,0.00001542085,0.000001561844,0.00002182307,0.00001139483,0.6568244,0.2175046,0.001925767,0.1219965],"study_design_scores_gemma":[0.0002268729,0.0000339173,0.0000198628,0.0003184152,0.00001720733,0.000001208888,0.00006646378,0.00006278614,0.3582256,0.03924685,0.6015735,0.0002072403],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.01018545,0.1265648,0.3112094,0.004527506,0.0002494675,0.003158114,0.00007858218,0.0007392097,0.5432874],"genre_scores_gemma":[0.4545383,0.3357321,0.1949528,0.001312544,0.0007073592,0.006187448,0.000441368,0.0001511545,0.00597688],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.5996478,"threshold_uncertainty_score":0.9999499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851365434570737,"score_gpt":0.3259984343146792,"score_spread":0.3074847799689718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}